Complex traits and quantitative genetics

Section edited by Jim Reecy

This section incorporates all aspects of complex trait and quantitative genetics including but not limited to: mapping and association studies, the genetic basis of disease, genetics aspects of breeding and linkage analysis.

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  1. Review

    Opportunities and challenges of whole-genome and -exome sequencing

    Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the p...

    Britt-Sabina Petersen, Broder Fredrich, Marc P. Hoeppner, David Ellinghaus and Andre Franke

    BMC Genetics 2017 18:14

    Published on: 14 February 2017

  2. Research article

    Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs

    One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3. I...

    Lucas L. Verardo, Marja-Liisa Sevón-Aimonen, Timo Serenius, Ville Hietakangas and Pekka Uimari

    BMC Genetics 2017 18:13

    Published on: 13 February 2017

  3. Research article

    ADAM23 is a common risk gene for canine idiopathic epilepsy

    Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we ...

    Lotta L. E. Koskinen, Eija H. Seppälä, Jutta Weissl, Tarja S. Jokinen, Ranno Viitmaa, Reetta L. Hänninen, Pascale Quignon, Andrea Fischer, Catherine André and Hannes Lohi

    BMC Genetics 2017 18:8

    Published on: 31 January 2017

  4. Research article

    Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position

    FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes.

    S. M. Heffernan, G. K. Stebbings, L. P. Kilduff, R. M. Erskine, S. H. Day, C. I. Morse, J. S. McPhee, C. J. Cook, B. Vance, W. J. Ribbans, S. M. Raleigh, C. Roberts, M. A. Bennett, G. Wang, M. Collins, Y. P. Pitsiladis…

    BMC Genetics 2017 18:4

    Published on: 19 January 2017

  5. Research article

    Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat

    Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established ...

    Miyako Suzuki, Misato Kobayashi, Tamio Ohno, Shinsaku Kanamori, Soushi Tateishi, Atsushi Murai and Fumihiko Horio

    BMC Genetics 2016 17:145

    Published on: 17 November 2016

  6. Research article

    Development, genetic mapping and QTL association of cotton PHYA, PHYB, and HY5-specific CAPS and dCAPS markers

    Among SNP markers that become increasingly valuable in molecular breeding of crop plants are the CAPS and dCAPS markers derived from the genes of interest. To date, the number of such gene-based markers is sma...

    Fakhriddin N. Kushanov, Alan E. Pepper, John Z. Yu, Zabardast T. Buriev, Shukhrat E. Shermatov, Sukumar Saha, Mauricio Ulloa, Johnie N. Jenkins, Abdusattor Abdukarimov and Ibrokhim Y. Abdurakhmonov

    BMC Genetics 2016 17:141

    Published on: 24 October 2016

  7. Research article

    Quantitative trait loci influencing forking defects in an outbred pedigree of loblolly pine

    The use of wood as an industrial raw material has led to development of plantation forestry, in which trees are planted, managed, and harvested as crops. The productivity of such plantations often exceeds that...

    Jin S. Xiong, Steven E. McKeand, Fikret Isik, Jill Wegrzyn, David B. Neale, Zhao-Bang Zeng, Luciano da Costa e Silva and Ross W. Whetten

    BMC Genetics 2016 17:138

    Published on: 18 October 2016

  8. Research article

    Adrenal cortex expression quantitative trait loci in a German Holstein × Charolais cross

    The importance of the adrenal gland in regard to lactation and reproduction in cattle has been recognized early. Caused by interest in animal welfare and the impact of stress on economically important traits i...

    Bodo Brand, Markus O. Scheinhardt, Juliane Friedrich, Daisy Zimmer, Norbert Reinsch, Siriluck Ponsuksili, Manfred Schwerin and Andreas Ziegler

    BMC Genetics 2016 17:135

    Published on: 6 October 2016

    The Erratum to this article has been published in BMC Genetics 2016 17:148

  9. Research article

    Genetic basis of nitrogen use efficiency and yield stability across environments in winter rapeseed

    Nitrogen use efficiency is an important breeding trait that can be modified to improve the sustainability of many crop species used in agriculture. Rapeseed is a major oil crop with low nitrogen use efficiency...

    Anne-Sophie Bouchet, Anne Laperche, Christine Bissuel-Belaygue, Cécile Baron, Jérôme Morice, Mathieu Rousseau-Gueutin, Jean-Eric Dheu, Pierre George, Xavier Pinochet, Thomas Foubert, Olivier Maes, Damien Dugué, Florent Guinot and Nathalie Nesi

    BMC Genetics 2016 17:131

    Published on: 15 September 2016

  10. Research article

    Mapping and validation of major quantitative trait loci for kernel length in wild barley (Hordeum vulgare ssp. spontaneum)

    Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study,...

    Hong Zhou, Shihang Liu, Yujiao Liu, Yaxi Liu, Jing You, Mei Deng, Jian Ma, Guangdeng Chen, Yuming Wei, Chunji Liu and Youliang Zheng

    BMC Genetics 2016 17:130

    Published on: 13 September 2016

  11. Research article

    An RGS2 3′UTR polymorphism is associated with preeclampsia in overweight women

    Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3′ UTR polymorphism of the Regula...

    Tiina Karppanen, Tea Kaartokallio, Miira M. Klemetti, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Anne Cathrine Staff and Hannele Laivuori

    BMC Genetics 2016 17:121

    Published on: 24 August 2016

  12. Research article

    Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures

    Results from genome-wide association studies (GWAS) identified many loci and biological pathways that influence adult body mass index (BMI). We aimed to identify if biological pathways related to adult BMI als...

    Claire Monnereau, Suzanne Vogelezang, Claudia J. Kruithof, Vincent W. V. Jaddoe and Janine F. Felix

    BMC Genetics 2016 17:120

    Published on: 18 August 2016

  13. Research article

    Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity

    Genome-wide association studies of Single Nucleotide Polymorphisms (SNPs) have identified 55 SNPs associated with lung function. However, little is known about the effect of copy number variants (CNVs) on lung...

    Nick Shrine, Martin D. Tobin, Claudia Schurmann, María Soler Artigas, Jennie Hui, Terho Lehtimäki, Olli T. Raitakari, Craig E. Pennell, Qi Wei Ang, David P. Strachan, Georg Homuth, Sven Gläser, Stephan B. Felix, David M. Evans, John Henderson, Raquel Granell…

    BMC Genetics 2016 17:116

    Published on: 11 August 2016

  14. Research article

    Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickens

    Earlobe color is a naturally and artificially selected trait in chicken. As a head furnishing trait, it has been selected as a breed characteristic. Research has demonstrated that white/red earlobe color was r...

    Changsheng Nie, Zebin Zhang, Jiangxia Zheng, Hongyan Sun, Zhonghua Ning, Guiyun Xu, Ning Yang and Lujiang Qu

    BMC Genetics 2016 17:115

    Published on: 5 August 2016

  15. Research article

    Estimation of genetic parameters and detection of chromosomal regions affecting the major milk proteins and their post translational modifications in Danish Holstein and Danish Jersey cattle

    In the Western world bovine milk products are an important protein source in human diet. The major proteins in bovine milk are the four caseins (CN), αS1-, αS2-, β-, and k-CN and the two whey proteins, β-LG and α...

    Bart Buitenhuis, Nina A. Poulsen, Grum Gebreyesus and Lotte B. Larsen

    BMC Genetics 2016 17:114

    Published on: 2 August 2016

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