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Table 6 Allele-wise analyses for prostate cancer risk in the multiethnic studies

From: Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men

    rs1447295     
    A allele frequency     
Author (Year) N cases/N controls Study population Cases Controls OR 95% CI p value
Amundadottir, et al. (2006) 1291/997 Iceland 0.17 0.11 1.72 1.7 × 10-9
  1435/779 Sweden 0.16 0.13 1.29 4.5 × 10-3
  458/247 European Americans 0.13 0.08 1.66 6.7 × 10-3
  246/352 African Americans 0.34 0.31 1.15 0.29
Freedman, et al. (2006) 70/68 Native Hawaiians 0.37 0.16 3.02 1.66 – 5.50 1.5 × 10-4
  449/465 Japanese Americans 0.24 0.17 1.48 1.18 – 1.86 3.4 × 10-4
  640/567 Latino Americans 0.14 0.10 1.48 1.14 – 1.91 1.4 × 10-3
  455/447 European Americans 0.13 0.10 1.35 1.01 – 1.80 0.02
  989/804 African Americans 1.05 0.95 – 1.16 0.15
Wang, et al. (2007) 491/545 Caucasians 0.12 0.10 1.16 0.85 – 1.58 0.25
  435/545 Caucasians* 0.17 0.10 1.93 1.37 – 2.72 4.0 × 10-3
Gudmundsson, et al. (2007) 1453/3064 Iceland 0.17 0.10 1.71 1.49 – 1.95 1.6 × 10-14
  385/892 Spain 0.10 0.07 1.44 1.07 – 1.94 1.7 × 10-2
  367/1302 The Netherlands 0.14 0.11 1.39 1.09 – 1.78 9.0 × 10-3
  373/372 African Americans 0.32 0.31 1.01 0.81 – 1.25 0.96
Haiman, et al. (2007) 1614/837 African Americans
  722/728 Japanese Americans
  111/112 Native Hawaiians
  637/633 Latino Americans
  1182/942 European Americans
Robbins, et al. (2007) 490/567 African Americans 0.34 0.31 1.40 0.70 – 1.30 0.13
Present study (2009) 391/323 Native Japanese 0.25 0.19 1.34 1.01 – 1.79 0.04
    rs6983267     
    G allele frequency     
Author (Year) N cases/N controls Study population Cases Controls OR 95% CI p value
Amundadottir, et al. (2006) 1291/997 Iceland
  1435/779 Sweden
  458/247 European Americans
  246/352 African Americans
Freedman, et al. (2006) 70/68 Native Hawaiians
  449/465 Japanese Americans
  640/567 Latino Americans
  455/447 European Americans
  989/804 African Americans
Wang, et al. (2007) 491/545 Caucasians
  435/545 Caucasians*
Gudmundsson, et al. (2007) 1453/3064 Iceland
  385/892 Spain
  367/1302 The Netherlands
  373/372 African Americans
Haiman, et al. (2007) 1614/837 African Americans 0.90 0.84 1.43 1.17 – 1.75
  722/728 Japanese Americans 0.37 0.32 1.22 1.05 – 1.42
  111/112 Native Hawaiians 0.36 0.28 1.29 0.88 – 1.89
  637/633 Latino Americans 0.63 0.62 1.05 0.89 – 1.24
  1182/942 European Americans 0.54 0.51 1.13 0.99 – 1.28
Robbins, et al. (2007) 490/567 African Americans 0.08 0.11 1.40 0.90 – 2.40 0.17
Present study (2009) 391/323 Native Japanese 0.38 0.31 1.27 0.99 – 1.62 0.06
  1. —, not applicable.
  2. *, Familial prostate cancer cases.
  3. †: We calculated the G allele frequencies of rs6983267. Genotype data were obtained from the supplementary Table 3 (reference No. 8).