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Figure 3 | BMC Genetics

Figure 3

From: Novel mutations in the VKORC1 gene of wild rats and mice – a response to 50 years of selection pressure by warfarin?

Figure 3

Alignment of VKORC1 proteins of different species. Amino acid substitutions which could be detected in the examined rats and mice are highlighted by grey shading. Black boxes indicate the predicted transmembrane domains (according to the topology model of Tie et al., 2005 [30]). Blue shaded amino acid residues refer to the CXXC motif which is supposed to be the active site of the VKORC1 protein. The TYA motif which is highlighted in pink is the proposed warfarin binding site [25].

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