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Figure 5 | BMC Genetics

Figure 5

From: A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation

Figure 5

Mutations that enhance the electrophysiological phenotype seen in Gl1/+ adult flies. (A) Traces from individual flies showing the response latency upon a single stimulus. Both yw controls and Gl1/+ flies show short response latencies. The addition of EG37/+ into the Gl1 background causes an increase in the latency. (B) Histograms showing the average response latencies recorded for all enhancers in the Gl1 background. The number of preparations tested (n) is given above each bar and latencies for flies containing Gl1/+ plus enhancers compared to flies containing Gl1/+ alone. *P < 0.05, **P < 0.01, ***P < 0.001 in unpaired Student's t-test. (C) Traces from individual flies showing following to 10 stimuli at 250 Hz. yw controls usually gave a response to each stimulus (1-10) whereas this was depressed in Gl1/+ individuals which often gave a response to stimuli 1-3 and then failed to respond to the remaining 7 stimuli. The addition of EG37/+ enhances this effect. (D-F) Graphs showing the average probability of a response for stimuli 1 through 10 at 250 Hz. The data for yw and Gl1/+ flies is shown in each panel for comparison against flies trans-heterozygous for Gl1/+ and the various enhancers. Enhancers EG37/+ and EG162/+ seemed to increase the depression seen in Gl1/+ flies with a decrease in the probability of obtaining a response with subsequent stimuli (D). Other enhancers either had no effect (E) or slightly increased the probability of a response from the late (7-10) stimuli (F).

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