Correcting for cryptic relatedness by a regression-based genomic control method

BMC Genomic Data

Table 2 Type I error of the uncorrected and GC or RGC-corrected tests under H₀: f₀ = f₁ = f₂ (nominal level is 0.05, a = (500, 1500), b = (1500, 500).

F	MAF	K	Method	T ₀	T _1/2	T ₁
0.01	p = 0.2	200	Uncorrected	0.350	0.557	0.539	0.509
			GC	0.032	0.056	0.067	0.045
			RGC	0.063	0.054	0.052	0.055
		300	Uncorrected	0.335	0.551	0.532	0.497
			GC	0.027	0.047	0.057	0.038
			RGC	0.055	0.053	0.051	0.052
	p = 0.45	200	Uncorrected	0.446	0.543	0.486	0.496
			GC	0.085	0.051	0.035	0.053
			RGC	0.052	0.052	0.054	0.049
		300	Uncorrected	0.464	0.550	0.487	0.512
			GC	0.096	0.049	0.037	0.058
			RGC	0.051	0.050	0.052	0.051
0.02	p = 0.2	200	Uncorrected	0.473	0.667	0.650	0.633
			GC	0.026	0.046	0.061	0.040
			RGC	0.065	0.053	0.052	0.056
		300	Uncorrected	0.452	0.679	0.662	0.637
			GC	0.022	0.048	0.060	0.035
			RGC	0.054	0.050	0.051	0.053
	p = 0.45	200	Uncorrected	0.591	0.665	0.612	0.627
			GC	0.101	0.047	0.038	0.060
			RGC	0.052	0.053	0.054	0.050
		300	Uncorrected	0.581	0.663	0.610	0.622
			GC	0.106	0.047	0.032	0.062
			RGC	0.051	0.052	0.053	0.052

ISSN: 2730-6844