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Table 4 Type I error of the uncorrected, GC and RGC-corrected tests when the markers are linked to the disease with probability 2% (nominal level is 0.05, K = 200, a = (500, 1500), b = (1500, 500), F = 0.02, f2, f1, f0 are the penetrances for AA, Aa, aa.)

From: Correcting for cryptic relatedness by a regression-based genomic control method

(f0, f1, f2)

MAF

Method

T 0

T 1/2

T 1

(0.01, 0.02, 0.02)

p = 0.2

Uncorrected

0.470

0.673

0.657

0.631

  

GC

0.021

0.041

0.055

0.035

  

RGC

0.064

0.051

0.047

0.058

(0.01, 0.015, 0.02)

 

Uncorrected

0.474

0.679

0.656

0.637

  

GC

0.018

0.042

0.056

0.034

  

RGC

0.056

0.052

0.051

0.054

(0.01, 0.01, 0.02)

 

Uncorrected

0.473

0.669

0.653

0.630

  

GC

0.022

0.040

0.054

0.039

  

RGC

0.063

0.052

0.053

0.055

(0.01, 0.02, 0.02)

p = 0.45

Uncorrected

0.592

0.668

0.615

0.630

  

GC

0.098

0.046

0.034

0.062

  

RGC

0.054

0.051

0.046

0.049

(0.01, 0.015, 0.02)

 

Uncorrected

0.608

0.675

0.619

0.638

  

GC

0.105

0.045

0.033

0.060

  

RGC

0.053

0.052

0.053

0.050

(0.01, 0.01, 0.02)

 

Uncorrected

0.598

0.670

0.620

0.631

  

GC

0.103

0.045

0.034

0.061

  

RGC

0.049

0.051

0.054

0.048