Neural networks for modeling gene-gene interactions in association studies

BMC Genomic Data

Table 4 Multiplicative model (MULT).

	Low risk	High risk
	a₁ = 2· a₀; a₂ = 4· a₀	a₁ = 5· a₀; a₂ = 10· a₀
	b₁ = 5· b₀; b₂ = 10· b₀	b₁ = 5· b₀; b₂ = 10· b₀
Theoretical penetrance matrix
Neural network
Mean absolute difference E
Sum	0.2428	0.2178
Logistic regression
Mean absolute difference E
Sum	0.3965	0.4887
Logistic regression (design variables)
Mean absolute difference E
Sum	0.1637	0.1833

Mean absolute differences between theoretical and estimated penetrance matrices from 100 replications in the low and high risk scenario.

ISSN: 2730-6844