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Figure 1 | BMC Genetics

Figure 1

From: Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomalies

Figure 1

Phenotype of the zebrafish out of sight mutant. (A - B) Lateral views of wild-type zebrafish (A) and of the outm233mutant (B) at 36 hpf, 48 hpf (a1 and b1), 72 hpf (a2 and b2) and 96 hpf (a3 and b3). The outm233mutant is characterized by a severe reduction in eye size. No obvious defects are observed in other organs. (C - D) Transverse plastic sections of wild-type (C) and outm233mutant (D) retinae at 36 hpf, 4 dpf (c1 and d1) and 5 dpf (c2 and d2). Although the retina and lens are grossly reduced in size in outm233mutants, their overall architectures appear largely intact. (E - F) An anophthalmic outm233homozygous mutant at ca. 2 months of age. An enlargement of the head region is shown in (F). (G - H) A wild-type individual (G) and its microphthalmic outm233sibling (H) at 2.5 months of age. In A, B, and E-H, anterior is to the left.

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