Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide

Leach, Richard J; Craigmile, Susan C; Knott, Sara A; Williams, John L; Glass, Elizabeth J

doi:10.1186/1471-2156-11-107

BMC Genomic Data

Table 1 All QTL located in this study

From: Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide

Chr¹	Trait²	cM³	F⁴	a⁵	d⁵	Var%⁶
2	IgG1_week_10	38	5.60	-0.21**	0.26**	5.71
3	IgG2_week_2	58	5.93	0.66**	0.40	6.03
4	IgG1_week_1	31	5.35	-0.63**	0.34	5.46
4	IgG1_week_8	20	5.17	0.12	0.17**	1.18
4	IgG1_week_10	27	4.92	0.23	-0.47*	5.05
4	IgG1_AUC	28	6.37*	0.11	-0.43*	6.64
4	SI_FMDV_Week_0	67	4.79	0.00	-0.14**	4.92
5	SI_CA_Week_0	68	8.10*	-0.13*	0.24**	8.05
5	SI_CA_Week_0	100	5.76	0.22**	-0.14	6.11
5	SI_CA_Week_10	76	5.26	-0.05	0.23**	5.38
5	SI_CA_10 ug_AUC	69	5.89	-0.06	0.17**	6.04
6	SI_CA_Week_0	30	8.69**	0.26***	0.08	8.59
6	SI_FMDV_Week_8	59	6.49	0.14**	-0.08	6.56
6	SI_FMDV_Week_8	133	7.35*	0.04	-0.20***	7.51
6	SI_FMDV_Week_10	3	6.61	0.12**	-0.15*	6.67
6	SI_FMDV_AUC	2	7.91*	0.10***	-0.07	7.96
6	SI_FMDV_AUC	133	6.21	0.03	-0.13**	6.56
7	IgG2_week_8	0	6.24	-0.85***	0.13	6.58
7	SI_CA_Week_10	0	4.89	0.05	0.28**	5.02
7	SI_FMDV_Week_4	54	5.45	-0.11**	-0.09	5.62
9	IgG1_week_0	40	5.29	-0.2948*	0.35	5.41
9	SI_FMDV_Week_10	63	4.92	0.05	-0.23**	5.05
11	IgG1_week_0	0	5.26	0.25	-0.61*	5.38
12	IgG2_week_8	17	5.44	-0.03	1.24***	5.56
13	IgG1_week_1	0	5.08	0.04	-0.54**	5.20
14	IgG2_week_0	2	4.85	0.12	-0.28**	4.98
15	IgG2_week_8	13	5.16	-0.08	1.03**	5.28
15	IgG2_AUC	27	5.39	-0.08	0.67**	5.51
16	IgG2_week_2	76	6.51	-0.71***	-0.16	6.58
16	SI_FMDV_AUC	64	4.42	-0.06*	-0.07*	4.61
18	SI_CA_Week_10	22	7.02*	-0.20***	0.10	7.06
18	IgG2_week_1	57	5.23	-0.10	0.34**	5.40
19	IgG2_week_2	28	4.93	-0.50*	-0.62*	5.06
19	IgG2_week_4	34	5.64	-0.73***	-0.32	5.75
19	IgG2_week_8	50	5.28	-0.81**	-0.25	5.63
19	SI_CA_Week_8	32	8.57*	0.25***	-0.07	8.48
19	SI_CA_Week_10	32	4.54	0.15*	-0.13	4.67
19	SI_CA_10 ug_AUC	28	4.42	0.13**	-0.01	4.61
20	IgG1_week_2	28	4.74	-0.03	0.48**	4.87
20	IgG1_week_4	36	7.86*	0.20**	0.35**	7.83
20	IgG1_week_8	9	6.49*	0.19	0.64**	6.56
20	IgG1_week_10	23	5.37	0.09	0.38**	5.48
20	IgG1_AUC	20	10.07***	0.12	0.39***	9.82
20	IgG2_week_4	32	7.48	0.52**	0.65*	7.48
20	IgG2_week_8	25	8.46	0.76**	0.87*	8.38
20	IgG2_week_10	31	6.23	0.33	0.82**	6.31
20	IgG2_AUC	31	8.5*	0.40**	0.67**	8.41
20	SI_FMDV_Week_0	61	7.95*	0.05	-0.18***	7.92
21	IgG1_week_2	69	4.96	-0.22*	0.38*	5.09
21	SI_CA_10 ug_AUC	84	4.10	-0.14**	-0.01	4.28
23	IgG1_week_0	78	5.11	-0.19	-0.54**	5.24
23	IgG1_week_1	65	5.83	-0.13	-0.87***	5.92
23	IgG1_week_2	39	4.16	0.37	-0.53	4.31
23	IgG1_week_10	18	5.25	0.37**	0.03	5.37
23	IgG1_AUC	18	5.34	0.29**	0.06	5.46
23	IgG2_week_4	0	5.45	0.63**	-0.18	5.57
23	IgG2_week_8	5	5.85	0.88***	-0.18	5.94
23	IgG2_week_10	33	4.08	1.02**	0.77	4.23
23	IgG2_AUC	6	6.61*	0.66***	-0.18	6.67
24	IgG1_week_8	35	7.83**	0.58***	0.32	7.80
24	IgG1_week_10	33	4.18	0.27**	0.06	4.32
24	IgG1_AUC	33	6.23	0.25***	0.12	6.31
24	IgG2_week_10	21	5.09	0.69**	0.61	5.32
24	SI_CA_Week_4	34	5.46	-0.05	0.28**	5.63
25	IgG1_week_0	0	4.48	0.34*	0.28	4.62
25	IgG1_week_1	0	4.88	0.29*	0.35*	5.01
25	IgG1_week_2	33	4.42	0.05	-0.35**	4.66
25	IgG2_week_1	15	4.48	0.18**	-0.11	4.62
25	IgG2_week_2	34	4.65	-0.14	-0.73**	4.78
25	IgG2_week_4	34	4.85	-0.14	-0.70**	4.98
25	IgG2_AUC	34	5.28	-0.04	-0.62**	5.40
25	SI_CA_Week_10	17	5.79	-0.11*	0.19**	5.89
26	IgG1_week_1	21	4.90	-0.30*	0.35	5.25
27	IgG2_week_4	7	4.61	-0.57**	-0.33	4.75
29	SI_CA_Week_0	0	5.34	0.15**	-0.11	5.69
29	SI_FMDV_Week_8	7	4.90	-0.10*	0.12	5.03
29	SI_FMDV_Week_10	0	4.38	-0.11**	0.08	4.61

1. Chr: the chromosome number of the QTL. Underlined if 2 QTL model.
2. Trait: each trait is shown as follows: trait type (IgG1; IgG2; SI_FMDV = T cell proliferation to the FMDV peptide; SI_CA = T cell proliferation to Concanavalin A), followed by week post immunisation.
3. cM: the position the QTL is on the chromosome, in centiMorgans.
4. F: the F-statistic for each QTL. Significance level: all are at least 5% chromosome wide, * = p < 1% chromosome wide, **= p < 5% genome wide and ***= p < 1% genome wide.
5. "a" and "d" are the additive and dominance effect, respectively, of each QTL, * = p < 5%, **= p < 1% and ***= p < 0.01%.
6. Var%: the phenotypic variance explained by the QTL.
Clusters of related traits have been boxed, 6 in total

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