Table 2 Genotypic frequencies and associations of SNPs in IL10, IL10RA/B, TGFB1, and SLC11A1 with MAP-infection status.
| Â | Â | Â | MAP infection status | Â | Â | |
|---|---|---|---|---|---|---|
| Â | Â | Â | Negative | Positive | Â | Â |
Gene | SNP | Genotype | # (%) | # (%) | Effect ± SE | OR (CI) |
IL10 | -285T > C | n | 208 | 178 | α: -0.29 ± 0.28 | 0.75 (0.43-1.29) |
|  |  | TT | 163 (78.4) | 136 (76.4) | δ: 0.45 ± 0.37 | 1.58 (0.76-3.29) |
| Â | Â | CT | 34 (16.3) | 37 (20.8) | Â | Â |
| Â | Â | CC | 11 (5.3) | 5 (2.8) | Â | Â |
IL10RA | 633C > A | n | 238 | 193 | α: -0.62 ± 0.32* | 0.54 (0.29-1.00) |
|  |  | CC | 10 (4.2) | 7 (3.6) | δ: -0.54 ± 0.36 | 0.58 (0.29-1.18) |
| Â | Â | CA | 72 (30.3) | 54 (28) | Â | Â |
| Â | Â | AA | 156 (65.5) | 132 (68.4) | Â | Â |
|  | 984G > A | n | 235 | 183 | α: -0.67 ± 0.22** | 0.51 (0.34-0.78) |
|  |  | AA | 56 (23.8) | 18 (9.8) | δ: 0.82 ± 0.25** | 2.27 (1.40-3.67) |
| Â | Â | AG | 111 (47.2) | 109 (59.6) | Â | Â |
| Â | Â | GG | 68 (28.9) | 56 (30.6) | Â | Â |
| Â | 1185C > T | n | 240 | 198 | rm | rm |
| Â | Â | TT | 18 (7.5) | 5 (2.5) | Â | Â |
| Â | Â | TC | 93 (38.8) | 75 (37.9) | Â | Â |
| Â | Â | CC | 129 (53.8) | 118 (59.6) | Â | Â |
IL10RB | 503C > T | n | 216 | 182 | α: 0.27 ± 0.17 | 1.31 (0.95-1.81) |
|  |  | CC | 36 (16.7) | 22 (12.1) | δ: 0.07 ± 0.22 | 1.08 (0.69-1.67) |
| Â | Â | TC | 103 (47.7) | 89 (48.9) | Â | Â |
| Â | Â | TT | 77 (35.6) | 71 (39) | Â | Â |
TGFB1 | 258C > T | n | 237 | 201 | α: 0.08 ± 0.16 | 1.08 (0.80-1.47) |
|  |  | CC | 98 (41.4) | 74 (36.8) | δ: 0.04 ± 0.22 | 1.04 (0.68-1.58) |
| Â | Â | CT | 106 (44.7) | 97 (48.3) | Â | Â |
| Â | Â | TT | 33 (13.9) | 30 (14.9) | Â | Â |
SLC11A1 | 1066C > G | n | 219 | 176 | α: -0.27 ± 0.37 | 0.77 (0.37-1.58) |
|  |  | CC | 142 (64.8) | 106 (60.2) | δ: 0.45 ± 0.41 | 1.57 (0.70-3.50) |
| Â | Â | CG | 71 (32.4) | 67 (38.1) | Â | Â |
| Â | Â | GG | 6 (2.7) | 3 (1.7) | Â | Â |