Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes

Boldt, Angelica BW; Messias-Reason, Iara J; Meyer, Diogo; Schrago, Carlos G; Lang, Florian; Lell, Bertrand; Dietz, Klaus; Kremsner, Peter G; Petzl-Erler, Maria Luiza; Kun, Jürgen FJ

doi:10.1186/1471-2156-11-38

BMC Genomic Data

Table 2 MBL2 haplotype frequencies (%) in diverse populations.

From: Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes

	*Afro-Gabonese* ⁽¹⁾	Afro-Americans²	German Europeans ⁽¹⁾	Euro-Americans²	Euro-Brazilians ⁽¹⁾
Haplotypes	N = 856 (N = 64)	N = 48	N = 208 (N = 48)	N = 62	N = 262
1A1-h ( LYPA* )	16.8 (9.5)	27.1	4.81 (8.3)	1.61	3.44
1A1.1B2-l ( LYPD* )	0	0	0	0	0.38
1B1-h ( HYPA* )	5.37 (6.3)	6.25	29.8 (41.7)	35.5	29.39
1B2-l ( HYPD* )	0.12 (0)	2.08	8.17 (10.4)	9.68	6.49
*1B3	0	0	0	0	0.38
1C1-l ( LXPA* )	14.6 (18.8)	14.6	21.6 (8.3) *	16.1	20.23
*1C2	0	0	0.48	0	0
*1D1-h	3.09 (0)	0	0	0	0
1E1-h ( LYPF* )	0.12 (0)	0	0	0	0
1F1-l ( LYPB* )	2.45 (1.6)	2.08	11.1 (10.4)	12.9	14.89
*1F2 ¶	0	0	0	0	0
*1G1-h	0.12 (0)	0	0	0	0
*1H1-h	7.01 (3.1)	6.25	0	0	1.15
*1H2-h	0.12 (0)	0	0	0	0.38
*1J1-h	0.82 (3.1)	0	0	0	0
*2A1-h	0.7 (0)	0	0	0	0
*3A1-h	0.12 (0)	0	0	0	0
4A1-h ( LYQA* )	25.6 (40.6) **	18.8	23.1 (20.9)	24.2	20.99
4B1-l ( LYQE* )	0.23 (0)	0	0	0	0
*4C1-h	0	0	0.48 (0)	0	0.76
*4D1-h	0.23 (1.6)	0	0	0	0
*4E1-h	5.37 (1.6)	6.25	0	0	0
4F1-l ( LYQC* )	16.7 (12.5)	14.6	0	0	0.76
*4F2A-l	1.75 (1.6)	0	0.48 (0)	0	0.76
*4F2B-l	0.58 (0)	0	0	0	0
*4F3-l	1.17 (0)	2.08	0	0	0
	North Chinese ^{3 (1)}	Hispanics ²	Pacific Rim ²	Guarani ⁴	Kaingang ^{4 (1)}
Haplotypes	N = 348 (N = 48)	N = 46	N = 48	N = 158	N = 126 (N = 26)
1A1-h ( LYPA* )	0	6.52	2.08	0.63	1.59 (0)
1A1.1B2-l ( LYPD* )	0	0	0	0	0
1B1-h ( HYPA* )	54.9 (31.3) **	28.3	45.8	48.1	52.4 (65.4)
1B2-l ( HYPD* )	0	4.35	0	0	0
*1B3	0	0	0	0	0
1C1-l ( LXPA* )	14.1 (22.9)	19.6	10.4	0	0.79 (0)
*1C2	0	0	0	0	0
*1D1-h	0	0	0	0	0
1E1-h ( LYPF* )	0	0	0	0	0
1F1-l ( LYPB* )	14.1 (29.2)^& **	13.0	16.7	47.5	26.2 (23.1)
*1F2	0	0	0	0	1.59 (0)
*1G1-h	0	0	0	0	0
*1H1-h	2.87 (4.2)	2.17	16.7	0	15.9 (11.5)
*1H2-h	0	0	0	0	0
*1J1-h	0	0	0	0	0
*2A1-h	0	0	0	0	0
*3A1-h	0	0	0	0	0
4A1-h ( LYQA* )	14.1 (6.3)	19.6	8.33	3.8	0.79 (0)
4B1-l ( LYQE* )	0	0	0	0	0
*4C1-h	0	0	0	0	0
*4D1-h	0	0	0	0	0
*4E1-h	0	2.17	0	0	0
4F1-l ( LYQC* )	0	2.17	0	0	0
*4F2A-l	0	2.17	0	0	0
*4F2B-l	0	0	0	0	0
*4F3-l	0	0	0	0	0.79 (0)

N number of chromosomes (N = 162 for 1D1-h in Afro-Gabonese, and this is why the sum of frequency values in this group did not equal exactly 100%). The distribution of MBL2 genotypes in the Gabonese adult sample as a whole was homogeneous with the distribution that we formerly found in a sample of 284 Gabonese children (39 malaria-free, 136 with uncomplicated malaria and 109 with severe malaria but not with cerebral malaria and/or severe hypoglycemia) [2]. In parentheses: differing values found in samples of smaller size but similar ethnic background (Gabonese Bantu, Danish, Chinese and Colombian Piapoco, respectively) [19]. & the Chinese investigated by others presented an additional LYPB haplotype with 6.3% frequency and a g.634G > A SNP (called by them -258 G > A) [19]. In italics: this work; 1 [19]; 2 [18]; 3 [28]; 4 [22].* p < 0.05 ** p < 0.01

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