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Table 1 Estimates of mutation age for MSH2 1906G > C1.

From: How old is this mutation? - a study of three Ashkenazi Jewish founder mutations

Method - Markers Estimated mutation age (generations) Estimated mutation age including correction for growth with r = 1.5 95% credible interval (DMLE) or 95% confidence interval (Goldgar)
Single marker results - median of 10 markers2 59.22 69.01  
Single marker results - median of 6 markers3 35.76 42.27  
DMLE with growth rate r = 1.5 N/A 16.84 [12.75, 22.45]
Goldgar method 11 17.623 Without growth [6, 20] With growth [13.62, 26.62]4
  1. 1 Estimates are from Sun et al. (2005) [17].
  2. 2 Results from the 10 markers, individually, are listed in Additional file 2.
  3. 3 The four markers closest to the mutation were excluded since recombination fractions cannot be accurately estimated at those distances.
  4. 4 A Labuda correction of 6.62 generations was applied. This is the median Labuda correction for the six markers further from the mutation.