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Table 2 Estimates of mutation age for APC I1307K.

From: How old is this mutation? - a study of three Ashkenazi Jewish founder mutations

Method Estimated mutation age (generations) Estimated mutation age including correction for growth with r = 1.125 Estimated mutation age including correction for growth with r = 1.21 95% credible interval (DMLE) or 95% confidence interval
Estimate from Niell et al. (2003)[5] 87.9 - 118    
Single marker - marker D5S1351,3 60.9 87.93 79.94  
Single marker - marker D5S3462,3 69.5 117.60 101.56  
DMLE N/A 105.76 69.16 r = 1.21: [56.00, 83.22]
r = 1.125: [85.96, 128.62]
Goldgar method3 28 65.57 53.55 r = 1.0: [20-39]
r = 1.125: [57.57, 76.57]
r = 1.21: [25.55, 64.55]
  1. 1 The recombination fraction used for D5S135 was 0.0046.
  2. 2 The recombination fraction used for D5S346 was 0.000385.
  3. 3 Labuda growth rate corrections are used for the single marker method and the Goldgar method.