From: How old is this mutation? - a study of three Ashkenazi Jewish founder mutations
Method | Estimated mutation age (generations) | Estimated mutation age assuming growth rate r = 1.125 | Estimated mutation age assuming growth rate r = 1.21 | 95% credible interval (DMLE) or 95% confidence interval (Goldgar) |
---|---|---|---|---|
Neuhausen et al. (1998) [13] | 29 | Â | Â | 1-LOD interval [22, 38] |
Single marker results, median of 28 markers1 | 25.17 | 38.94 | 36.02 | Â |
DMLE, 6 markers | N/A | 81.27 | 51.77 | r = 1.125: [62.13, 102.34] r = 1.21: [40.53, 64.78] |
DMLE, 10 markers | N/A | 88.56 | 58.65 | r = 1.125:[67.19, 113.57] r = 1.21:[45.48, 74.46] |
DMLE, 14 markers | N/A | 90.50 | 60.53 | r = 1.125:[71.37, 114.24] r = 1.21:[48.49, 75.23] |
Goldgar method2, 6 markers | 9 | 33.31 | 25.42 | r = 1.0: [≤ 1, 124] r = 1.125: [≤ 24.31,148.31] r = 1.21 [≤ 17.42,141.42] |
Goldgar method2, 10 markers | 17 | 41.31 | 34.42 | r = 1.0: [≤ 1, 70] r = 1.125: [≤ 24.31, 94.31] r = 1.25: [≤ 17.42, 87.42] |
Goldgar method2, 14 markers | 15 | 39.31 | 32.42 | r = 1.0: [≤ 1, 42] r = 1.125: [≤ 24.31, 66.31] r = 1.21: ≤ 17.42, 59.42] |