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Table 3 Estimates of mutation age for BRCA2 6174delT.

From: How old is this mutation? - a study of three Ashkenazi Jewish founder mutations

Method

Estimated mutation age (generations)

Estimated mutation age assuming growth rate r = 1.125

Estimated mutation age assuming growth rate r = 1.21

95% credible interval (DMLE) or 95% confidence interval (Goldgar)

Neuhausen et al. (1998) [13]

29

  

1-LOD interval [22, 38]

Single marker results, median of 28 markers1

25.17

38.94

36.02

 

DMLE, 6 markers

N/A

81.27

51.77

r = 1.125: [62.13, 102.34]

r = 1.21: [40.53, 64.78]

DMLE, 10 markers

N/A

88.56

58.65

r = 1.125:[67.19, 113.57]

r = 1.21:[45.48, 74.46]

DMLE, 14 markers

N/A

90.50

60.53

r = 1.125:[71.37, 114.24]

r = 1.21:[48.49, 75.23]

Goldgar method2, 6 markers

9

33.31

25.42

r = 1.0: [≤ 1, 124]

r = 1.125: [≤ 24.31,148.31]

r = 1.21 [≤ 17.42,141.42]

Goldgar method2, 10 markers

17

41.31

34.42

r = 1.0: [≤ 1, 70]

r = 1.125: [≤ 24.31, 94.31]

r = 1.25: [≤ 17.42, 87.42]

Goldgar method2, 14 markers

15

39.31

32.42

r = 1.0: [≤ 1, 42]

r = 1.125: [≤ 24.31, 66.31]

r = 1.21: ≤ 17.42, 59.42]

  1. 1The single marker result shows the median estimate of mutation age across 28 out of 48 markers near the mutation for which a single marker estimate was possible (see Additional file 3). The correction for growth was based on the median Labuda correction across 28 markers for which a single marker estimate of mutation age was possible.
  2. 2Labuda corrections for growth are used.