MAF | Polygenic Variance | LM | LME | FBAT | LM-LME 1 | Three-stage |
---|
0.1 | 0.3 | 0.22 | 0.01 | 0.02 | 0.01 | 0.01 |
0.1 | 0.6 | 0.78 | 0.01 | 0.02 | 0.01 | 0 |
- Marginal phenotype distribution follows the standard normal distribution.
- LM_LME1: two-stage approach with LM at first stage with p-value cut-off 0.1 and LME at second stage with p-value cut-off 1e-6.
- Three-stage: LM at first stage with p-value cut-off 0.1, LME at second stage with p-value cut-off 1e-6 and FBAT at third stage with p-value cut-off 0.05/n, where n is the number of SNPs entering the third stage.