Table 2 Interactions between GST genotypes, alcohol consumption, tobacco smoking and fuel source among oesophageal cancer patients and controls
From: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer
Genotypes | Patients N(%) | Controls N(%) | OR (95%CI) p-value | Patients N(%) | Controls N (%) | OR (95%CI) p-value |
|---|---|---|---|---|---|---|
| Â | Tobacco smokers a | Non smokers a | ||||
GSTT1*1 | 100 (56) | 112 (61) | 1.00 | 27 (43) | 66 (69) | 1.00 |
GSTT1*0 | 77 (44) | 73 (39) | 1.01 (0.62-1.66) 0.951 | 36 (57) | 29 (31) | 2.92(1.04-8.16) 0.042 |
GSTM1*1 | 151 (85) | 125 (68) | 1.00 | 55 (87) | 75 (79 | 1.00 |
GSTM1*0 | 125 (15) | 60 (32) | 0.30 (0.16-0.56) 0.001 | 8 (13) | 20 (21) | 0.46 (0.12-1.81) 0.269 |
GSTP1 313A/A | 71 (40) | 77 (42) | 1.00 | 21 (33) | 30 (32) | 1.00 |
GSTP1 313 A/G | 78 (44) | 86 (46) | 0.96 (0.58-1.61) 0.898 | 33 (52) | 48 (50) | 0.53 (0.18-1.51) 0.233 |
GSTP1 313G/G | 28 (16) | 22 (12) | 1.54 (0.74-3.21) 0.250 | 9 (14) | 17 (18) | 0.44 (0.10-1.93) 0.278 |
GSTP1 341 C/C | 106 (60) | 166 (90) | 1.00 | 44 (70) | 86 (91) | 1.00 |
GSTP1-341C/T + GSTP1-341T/T | 71 (40) | 19 (10) | 7.51 (3.82-14.7) 0.001 | 19 (30) | 9 (9) | 5.31 (2.58-27.6) 0.001 |
| Â | Alcohol consumers b | Non consumers b | ||||
GSTT1*1 | 89 (54) | 101 (60) | 1.00 | 38 (51) | 77 (68) | 1.00 |
GSTT1*0 | 76 (46) | 66 (40) | 1.03 (0.60-1.77) 0.911 | 37 (49) | 36 (32) | 1.66 (0.77-3.59) 0.197 |
GSTM1*1 | 143 (87) | 123 (74) | 1.00 | 63 (84) | 77 (68) | 1.00 |
GSTM1*0 | 22 (13) | 44 (26) | 0.33 (0.16-0.66) 0.002 | 12 (16) | 36 (32) | 0.27 (0.10-0.74) 0.011 |
GSTP1 313A/A | 63 (38) | 74 (44) | 1.00 | 29 (39) | 33 (29) | 1.00 |
GSTP1 313 A/G | 80 (48) | 75 (45) | 1.22 (0.70-2.13) 0.474 | 31 (41) | 58 (52) | 0.41 (0.17-0.96) 0.039 |
GSTP1 313G/G | 22 (13) | 18 (11) | 1.69 (0.72-3.95) 0.226 | 15 (20) | 22 (19) | 0.64 (0.24-1.76) 0.394 |
GSTP1 341 C/C | 105 (64) | 148 (89) | 1.00 | 45 (60) | 104 (92) | 1.00 |
GSTP1-341C/T + GSTP1-341T/T | 60 (36) | 19 (11) | 15.3 (1.81-12.9) 0.012 | 30 (40) | 9 (8) | 10.9 (4.09-28.9) 0.001 |
| Â | Wood or charcoal users c | Non users c | ||||
GSTT1*1 | 54 (61) | 25(58) | 1.00 | 52 (60) | 153 (65) | 1.00 |
GSTT1*0 | 34 (39) | 18 (42) | 0.77 (0.35-1.68) 0.510 | 35 (40) | 84 (35) | 1.67 (0.94-2.93) 0.080 |
GSTM1*1 | 72 (82) | 27 (63) | 1.00 | 77 (89) | 173 (73) | 1.00 |
GSTM1*0 | 16 (18) | 16 (37) | 0.41 (0.17-0.96) 0.041 | 10 (11) | 64 (27) | 0.26 (0.12-0.56) 0.001 |
GSTP1 313A/A | 38 (43) | 17 (40) | 1.00 | 34 (39) | 90 (38) | 1.00 |
GSTP1 313 A/G | 34 (39) | 23 (53) | 0.71 (0.30-1.69) 0.441 | 41 (47) | 110 (46) | 0.97 (0.55-1.73) 0.922 |
GSTP1 313G/G | 16 (18) | 3 (7) | 3.28 (0.79-13.7) 0.103 | 12 (14) | 37 (16) | 1.11 (0.48-2.53) 0.809 |
GSTP1 341 C/C | 42 (48) | 40 (93) | 1.00 | 57 (66) | 212 (89) | 1.00 |
GSTP1-341C/T + GSTP1-341T/T | 46 (52) | 3 (7) | 12.1 (3.26-49.0) 0.001 | 30 (34) | 25 (11) | 4.93 (2.47-9.84) 0.001 |