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Table 2 Population allele frequencies stratified by self reported race

From: Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

Gene Polymorphism Allele
(MA)
Population
MAF
(95% CI)
White/
Caucasian
MAF
(95% CI)
White
Hispanic
MAF
(95% CI)
Black
African American
MAF
(95% CI)
Asian
Hmong
MAF
(95% CI)
American
Indian
MAF
(95% CI)
P value
LEPR rs1137101 G(A) 0.459
(0.454-0.464)
0.544
(0.539-0.549)
0.493
(0.445-0.541)
0.410
(0.314-0.506)
0.330
(0.263-0.397)
0.479
(0.425-0.533)
<0.0001
RNASEL rs486907 G(A) 0.375
(0.370-0.380)
0.379
(0.374-0.384)
0.214
(0.174-0.254)
0.100
(0.041-0.159)
0.308
(0.242-0.374)
0.284
(0.236-0.332)
<0.0001
APOB rs1042031 G(A) 0.180
(0.176-0.184)
0.18
(0.176-0.184)
0.167
(0.131-0.203)
0.220
(0.139-0.301)
0.063
(0.028-0.098)
0.182
(0.141-0.223)
0.0023
CTLA4 rs231775 A(G) 0.388
(0.383-0.393)
0.386
(0.381-0.391)
0.480
(0.432-0.528)
0.370
(0.275-0.465)
0.479
(0.408-0.550)
0.413
(0.360-0.466)
<0.0001
AGTR1 rs5186 A(C) 0.298
(0.293-0.303)
0.299
(0.294-0.304)
0.306
(0.262-0.350)
0.110
(0.049-0.171)
0.106
(0.062-0.150)
0.287
(0.238-0.336)
<0.0001
DRD3 rs6280 T(C) 0.315
(0.310-0.320)
0.311
(0.306-0.316)
0.480
(0.432-0.528)
0.240
(0.156-0.324)
0.297
(0.232-0.362)
0.359
(0.308-0.410)
<0.0001
FABP2 rs1799883 G(A) 0.262
(0.258-0.266)
0.261
(0.257-0.265)
0.293
(0.249-0.337)
0.240
(0.156-0.324)
0.250
(0.188-0.312)
0.295
(0.246-0.344)
0.3968
ADD1 rs4961 G(T) 0.192
(0.188-0.196)
0.191
(0.187-0.195)
0.209
(0.170-0.248)
0.100
(0.041-0.159)
0.346
(0.278-0.414)
0.165
(0.125-0.205)
<0.0001
ADRB2 rs1042714 C(G) 0.428
(0.423-0.433)
0.433
(0.428-0.438)
0.214
(0.174-0.254)
0.250
(0.165-0.335)
0.170
(0.116-0.224)
0.404
(0.351-0.457)
<0.0001
FGFR4 rs351855 C(T) 0.305
(0.300-0.310)
0.303
(0.298-0.308)
0.430
(0.382-0.478)
0.170
(0.096-0.244)
0.436
(0.365-0.507)
0.314
(0.264-0.364)
<0.0001
EDN1 rs5370 G(T) 0.213
(0.209-0.217)
0.214
(0.210-0.218)
0.182
(0.145-0.219)
0.180
(0.105-0.255)
0.255
(0.193-0.317)
0.165
(0.125-0.205)
0.0835
HTR1B rs6296 G(C) 0.270
(0.266-0.274)
0.268
(0.264 -0.272)
0.391
(0.344-0.438)
0.220
(0.139-0.301)
0.367
(0.298-0.436)
0.320
(0.270-0.370)
<0.0001
EGFR rs2227983 G(A) 0.255
(0.251-0.259)
0.253
(0.249-0.257)
0.313
(0.268-0.358)
0.090
(0.034-0.146)
0.527
(0.456-0.598)
0.275
(0.227-0.323)
<0.0001
CFTR rs213950 G(A) 0.428
(0.423-0.433)
0.426
(0.421-0.431)
0.512
(0.464-0.560)
0.760
(0.676-0.844)
0.484
(0.413-0.555)
0.389
(0.337-0.441)
<0.0001
PON2 rs7493 C(G) 0.244
(0.240-0.248)
0.244
(0.240-0.248)
0.231
(0.190-0.272)
0.350
(0.257-0.443)
0.245
(0.184-0.306)
0.207
(0.164-0.250)
0.2519
LPL rs328 C(G) 0.098
(0.095-0.101)
0.098
(0.095-0.101)
0.083
(0.056-0.110)
0.080
(0.027-0.133)
0.080
(0.041-0.119)
0.108
(0.075-0.141)
0.9200
9p21 rs2383206 A(G) 0.500
(0.495-0.505)
0.499
(0.494-0.504)
0.551
(0.503-0.599)
0.550
(0.452-0.648)
0.505
(0.434-0.576)
0.547
(0.494-0.600)
0.2803
RET rs1800861 A(C) 0.233
(0.229-0.237)
0.232
(0.228-0.236)
0.218
(0.178-0.258)
0.130
(0.064-0.196)
0.452
(0.381-0.523)
0.219
(0.175-0.263)
<0.0001
ADRB1 rs1801253 C(G) 0.270
(0.266-0.274)
0.271
(0.267-0.275)
0.163
(0.127-0.199)
0.500
(0.402-0.598)
0.229
(0.169-0.289)
0.222
(0.177-0.267)
<0.0001
PLAU rs2227564 C(T) 0.247
(0.243-0.251)
0.247
(0.243-0.251)
0.250
(0.208-0.292)
0.100
(0.041-0.159)
0.299
(0.234-0.364)
0.246
(0.200-0.292)
0.354
MMP1 rs1799750 -(G) 0.471
(0.466-0.476)
0.469
(0.464-0.474)
0.638
(0.592-0.684)
0.460
(0.362-0.558)
0.565
(0.494-0.636)
0.494
(0.440-0.548)
<0.0001
VWF rs1063856 A(G) 0.359
(0.354-0.364)
0.361
(0.356-0.366)
0.250
(0.208-0.292)
0.490
(0.392-0.588)
0.170
(0.116-0.224)
0.290
(0.241-0.339)
<0.0001
HTR2A rs6313 C(T) 0.406
(0.401-0.411)
0.406
(0.401-0.411)
0.369
(0.322-0.416)
0.350
(0.257-0.443)
0.450
(0.379-0.521)
0.392
(0.340-0.444)
0.3286
MTHFD1 rs2236225 C(T) 0.448
(0.443-0.453)
0.447
(0.442-0.452)
0.578
(0.530-0.626)
0.240
(0.156-0.324)
0.293
(0.228-0.358)
0.476
(0.422-0.530)
<0.0001
LIPC rs1800588 C(T) 0.218
(0.214-0.222)
0.214
(0.210-0.218)
0.480
(0.432-0.528)
0.430
(0.333-0.527)
0.346
(0.278-0.414)
0.254
(0.207-0.301)
<0.0001
MMP2 rs243865 C(T) 0.246
(0.242-0.250)
0.247
(0.243-0.251)
0.218
(0.178-0.258)
0.100
(0.041-0.159)
0.112
(0.067-0.157)
0.257
(0.210-0.304)
<0.0001
CYBA rs4673 C(T) 0.339
(0.334-0.344)
0.341
(0.336-0.346)
0.209
(0.170-0.248)
0.370
(0.275-0.465)
0.213
(0.154-0.272)
0.371
(0.319-0.423)
<0.0001
CETP rs708272 C(T) 0.421
(0.416-0.426)
0.422
(0.417-0.427)
0.432
(0.384-0.480)
0.306
(0.216-0.396)
0.398
(0.328-0.468)
0.428
(0.375-0.481)
0.0924
ELAC2 rs4792311 G(A) 0.303
(0.298-0.308)
0.304
(0.299-0.309)
0.262
(0.220-0.304)
0.280
(0.192-0.368)
0.165
(0.112-0.218)
0.317
(0.267-0.367)
<0.0001
ENOSF1/TYMS rs16430 +(-) 0.299
(0.294-0.304)
0.297
(0.292-0.302)
0.347
(0.301-0.393)
0.470
(0.372-0.568)
0.585
(0.515-0.655)
0.293
(0.244-0.342)
<0.0001
FUT2 rs601338 G(A)   0.456
(0.451-0.461)
0.267
(0.224-0.310)
0.500
(0.402-0.598)
0.133
(0.084-0.182)
0.410
(0.357-0.463)
<0.0001
LDLR rs688 C(T) 0.422
(0.417-0.427)
0.423
(0.418-0.428)
0.425
(0.377-0.473)
0.150
(0.080-0.220)
0.335
(0.268-0.402)
0.467
(0.413-0.521)
<0.0001
GNAS rs7121 C(T) 0.480
(0.475-0.485)
0.477
(0.472-0.482)
0.575
(0.527-0.623)
0.700
(0.610-0.790)
0.606
(0.536-0.676)
0.545
(0.492-0.598)
<0.0001
CBS rs234706 G(A) 0.345
(0.340-0.350)
0.348
(0.343-0.353)
0.233
(0.192-0.274)
0.220
(0.139-0.301)
0.118
(0.072-0.164)
0.335
(0.284-0.386)
<0.0001
IL1B rs16944 G(A) 0.334
(0.329-0.339)
0.329
(0.324-0.334)
0.566
(0.518-0.614)
0.550
(0.452-0.648)
0.500
(0.429-0.571)
0.437
(0.384-0.490)
<0.0001
NOS3 rs1799983 G(T) 0.306
(0.301-0.311)
0.308
(0.303-0.313)
0.228
(0.187-0.269)
0.130
(0.064-0.196)
0.149
(0.098-0.200)
0.263
(0.216-0.310)
<0.0001
TGFB1 rs1800469 C(T) 0.308
(0.303-0.313)
0.306
(0.301-0.311)
0.468
(0.420-0.516)
0.250
(0.165-0.335)
0.410
(0.340-0.480)
0.287
(0.238-0.336)
<0.0001
TNFa rs1800629 G(A) 0.170
(0.166-0.174)
0.171
(0.167-0.175)
0.083
(0.056-0.110)
0.160
(0.088-0.232)
0.080
(0.041-0.119)
0.132
(0.096-0.168)
<0.0001
IL6 rs1800795 G(C) 0.434
(0.429-0.439)
0.440
(0.435-0.445)
0.199
(0.160-0.238)
0.160
(0.088-0.232)
0.085
(0.045-0.125)
0.326
(0.276-0.376)
<0.0001
IL6 rs1800796 G(C) 0.057
(0.055-0.059)
0.052
(0.050-0.054)
0.260
(0.218-0.302)
0.110
(0.049-0.171)
0.479
(0.408-0.550)
0.111
(0.077-0.145)
<0.0001
IL10 rs1800872 C(A) 0.244
(0.240-0.248)
0.240
(0.236-0.244)
0.362
(0.316-0.408)
0.350
(0.257-0.443)
0.553
(0.482-0.624)
0.269
(0.221-0.317)
<0.0001
MTHFR rs1801133 C(T) 0.327
(0.322-0.332)
0.327
(0.322-0.332)
0.485
(0.437-0.533)
0.100
(0.041-0.159)
0.229
(0.169-0.289)
0.344
(0.293-0.395)
<0.0001
LPL rs268 A(G) 0.020
(0.019-0.021)
0.020
(0.019-0.021)
0.001
(0.000-0.004)
0 0 0.015
(0.002-0.028)
NA
ACE rs4291 A(T) 0.377
(0.372-0.382)
0.389
(0.384-0.394)
0.415
(0.367-0.463)
0.347
(0.254-0.440)
0.316
(0.250-0.382)
0.377
(0.325-0.429)
0.2086
ACE rs4343 G(A) 0.481
(0.476-0.486)
0.479
(0.474-0.484)
0.556
(0.508-0.604)
0.710
(0.621-0.799)
0.580
(0.509-0.651)
0.488
(0.434-0.542)
<0.0001
APOE rs429358 T(C) 0.144
(0.141-0.147)
0.145
(0.141-0.149)
0.100
(0.071-0.129)
0.220
(0.139-0.301)
0.085
(0.045-0.125)
0.123
(0.088-0.158)
0.0108
APOE rs7412 C(T) 0.083
(0.080-0.086)
0.083
(0.080-0.086)
0.030
(0.014-0.046)
0.140
(0.072-0.208)
0.060
(0.026-0.094)
0.084
(0.054-0.114)
0.0056
COMT rs4680 A(G) 0.469
(0.464-0.474)
0.466
(0.461-0.471)
0.570
(0.522-0.618)
0.690
(0.599-0.781)
0.654
(0.586-0.722)
0.461
(0.408-0.514)
<0.0001
VDR rs7975232 A(C) 0.485
(0.480-0.490)
0.483
(0.478-0.488)
0.573
(0.525-0.621)
0.410
(0.314-0.506)
0.633
(0.564-0.702)
0.500
(0.446-0.554)
<0.0001
VDR rs731236 T(C) 0.384
(0.379-0.389)
0.387
(0.382-0.392)
0.245
(0.203-0.287)
0.320
(0.229-0.411)
0.165
(0.112-0.218)
0.359
(0.308-0.410)
<0.0001
VDR rs1544410 G(A) 0.389
(0.384-0.394)
0.392
(0.387-0.397)
0.243
(0.202-0.284)
0.310
(0.219-0.401)
0.223
(0.163-0.283)
0.344
(0.293-0.395)
<0.0001