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Table 3 Population Caucasian allele frequencies stratified by self reported region of ancestry

From: Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

Gene Polymorphism Allele
(MA)
White
Caucasian
MAF
(95% CI)
British and Irish Isles
MAF
(95% CI)
Eastern Europe
MAF
(95% CI)
Germany
MAF
(95% CI)
Scandinavia
MAF
(95% CI)
P value
LEPR rs1137101 G(A) 0.544
(0.539-0.549)
0.554
(0.536-0.572)
0.523
(0.498-0.548)
0.544
(0.536-0.552)
0.500
(0.473-0.527)
0.032
RNASEL rs486907 G(A) 0.379
(0.374-0.384)
0.363
(0.345-0.381)
0.381
(0.357-0.405)
0.384
(0.377-0.391)
0.376
(0.350-0.402)
0.553
APOB rs1042031 G(A) 0.18
(0.176-0.184)
0.190
(0.176-0.204)
0.179
(0.160-0.198)
0.184
(0.178-0.190)
0.153
(0.133-0.173)
0.143
CTLA4 rs231775 A(G) 0.386
(0.381-0.391)
0.394
(0.376-0.412)
0.422
(0.397-0.447)
0.373
(0.366-0.380)
0.422
(0.395-0.449)
<0.0001
AGTR1 rs5186 A(C) 0.299
(0.294-0.304)
0.298
(0.281-0.315)
0.285
(0.263-0.307)
0.305
(0.298-0.312)
0.278
(0.254-0.302)
0.185
DRD3 rs6280 T(C) 0.311
(0.306-0.316)
0.342
(0.325-0.359)
0.270
(0.248-0.292)
0.316
(0.309-0.323)
0.306
(0.281-0.331)
0.0001
FABP2 rs1799883 G(A) 0.261
(0.257-0.265)
0.261
(0.245-0.277)
0.258
(0.236-0.280)
0.261
(0.254-0.268)
0.271
(0.247-0.295)
0.871
ADD1 rs4961 G(T) 0.191
(0.187-0.195)
0.188
(0.174-0.202)
0.165
(0.147-0.183)
0.192
(0.186-0.198)
0.197
(0.175-0.219)
0.158
ADRB2 rs1042714 C(G) 0.433
(0.428-0.438)
0.457
(0.439-0.475)
0.403
(0.379-0.427)
0.428
(0.420-0.436)
0.419
(0.392-0.446)
0.0018
FGFR4 rs351855 C(T) 0.303
(0.298-0.308)
0.286
(0.269-0.303)
0.351
(0.327-0.375)
0.299
(0.292-0.306)
0.330
(0.304-0.356)
<0.0001
EDN1 rs5370 G(T) 0.214
(0.210-0.218)
0.218
(0.203-0.233)
0.193
(0.173-0.213)
0.210
(0.204-0.216)
0.201
(0.179-0.223)
0.524
HTR1B rs6296 G(C) 0.268
(0.264-0.272)
0.266
(0.250-0.282)
0.281
(0.259-0.303)
0.264
(0.257-0.271)
0.290
(0.265-0.315)
0.045
EGFR rs2227983 G(A) 0.253
(0.249-0.257)
0.265
(0.249-0.281)
0.260
(0.238-0.282)
0.250
(0.243-0.257)
0.260
(0.236-0.284)
0.209
CFTR rs213950 G(A) 0.426
(0.421-0.431)
0.423
(0.405-0.441)
0.444
(0.419-0.469)
0.427
(0.419-0.435)
0.424
(0.397-0.451)
0.085
PON2 rs7493 C(G) 0.244
(0.240-0.248)
0.252
(0.236-0.268)
0.279
(0.257-0.301)
0.239
(0.233-0.245)
0.257
(0.233-0.281)
0.004
LPL rs328 C(G) 0.098
(0.095-0.101)
0.099
(0.088-0.110)
0.092
(0.078-0.106)
0.099
(0.094-0.104)
0.090
(0.074-0.106)
0.682
9p21 rs2383206 A(G) 0.499
(0.494-0.504)
0.522
(0.504-0.540)
0.496
(0.471-0.521)
0.495
(0.487-0.503)
0.477
(0.450-0.504)
0.150
RET rs1800861 A(C) 0.232
(0.228-0.236)
0.213
(0.198-0.228)
0.256
(0.234-0.278)
0.240
(0.234-0.246)
0.203
(0.181-0.225)
0.001
ADRB1 rs1801253 C(G) 0.271
(0.267-0.275)
0.264
(0.248-0.280)
0.269
(0.247-0.291)
0.270
(0.263-0.277)
0.275
(0.251-0.299)
0.922
PLAU rs2227564 C(T) 0.247
(0.243-0.251)
0.239
(0.223-0.255)
0.219
(0.198-0.240)
0.244
(0.237-0.251)
0.277
(0.253-0.301)
0.012
MMP1 rs1799750 -(G) 0.469
(0.464-0.474)
0.486
(0.468-0.504)
0.458
(0.433-0.483)
0.460
(0.452-0.468)
0.505
(0.478-0.532)
0.020
VWF rs1063856 A(G) 0.361
(0.356-0.366)
0.381
(0.363-0.399)
0.337
(0.314-0.360)
0.353
(0.346-0.360)
0.372
(0.346-0.398)
0.006
HTR2A rs6313 C(T) 0.406
(0.401-0.411)
0.400
(0.382-0.418)
0.370
(0.346-0.394)
0.412
(0.405-0.419)
0.397
(0.370-0.424)
0.071
MTHFD1 rs2236225 C(T) 0.447
(0.442-0.452)
0.456
(0.438-0.474)
0.442
(0.417-0.467)
0.446
(0.438-0.454)
0.439
(0.412-0.466)
0.792
LIPC rs1800588 C(T) 0.214
(0.210-0.218)
0.225
(0.210-0.240)
0.232
(0.211-0.253)
0.213
(0.207-0.219)
0.212
(0.190-0.234)
0.077
MMP2 rs243865 C(T) 0.247
(0.243-0.251)
0.242
(0.226-0.258)
0.257
(0.235-0.279)
0.243
(0.236-0.250)
0.248
(0.225-0.271)
0.888
CYBA rs4673 C(T) 0.341
(0.336-0.346)
0.318
(0.301-0.335)
0.365
(0.341-0.389)
0.338
(0.331-0.345)
0.325
(0.300-0.350)
0.083
CETP rs708272 C(T) 0.422
(0.417-0.427)
0.436
(0.418-0.454)
0.409
(0.385-0.433)
0.420
(0.413-0.427)
0.436
(0.409-0.463)
0.027
ELAC2 rs4792311 G(A) 0.304
(0.299-0.309)
0.291
(0.274-0.308)
0.304
(0.281-0.327)
0.309
(0.302-0.316)
0.292
(0.267-0.317)
0.492
ENOSF1/TYMS rs16430 +(-) 0.297
(0.292-0.302)
0.301
(0.284-0.318)
0.273
(0.251-0.295)
0.300
(0.293-0.307)
0.305
(0.280-0.330)
0.314
FUT2 rs601338 G(A) 0.456
(0.451-0.461)
0.486
(0.468-0.504)
0.394
(0.370-0.418)
0.452
(0.444-0.460)
0.502
(0.475-0.529)
<0.0001
LDLR rs688 C(T) 0.423
(0.418-0.428)
0.443
(0.425-0.461)
0.406
(0.382-0.430)
0.421
(0.414-0.428)
0.420
(0.393-0.447)
0.038
GNAS rs7121 C(T) 0.477
(0.472-0.482)
0.500
(0.482-0.518)
0.468
(0.443-0.493)
0.475
(0.467-0.483)
0.473
(0.446-0.500)
0.317
CBS rs234706 G(A) 0.348
(0.343-0.353)
0.342
(0.325-0.359)
0.331
(0.308-0.354)
0.347
(0.340-0.354)
0.344
(0.318-0.370)
0.266
IL1B rs16944 G(A) 0.329
(0.324-0.334)
0.343
(0.326-0.360)
0.326
(0.303-0.349)
0.332
(0.325-0.339)
0.312
(0.287-0.337)
0.170
NOS3 rs1799983 G(T) 0.308
(0.303-0.313)
0.318
(0.301-0.335)
0.287
(0.265-0.309)
0.309
(0.302-0.316)
0.296
(0.271-0.321)
0.420
TGFB1 rs1800469 C(T) 0.306
(0.301-0.311)
0.299
(0.282-0.316)
0.320
(0.297-0.343)
0.309
(0.302-0.316)
0.296
(0.271-0.321)
0.742
TNFa rs1800629 G(A) 0.171
(0.167-0.175)
0.189
(0.175-0.203)
0.156
(0.138-0.174)
0.169
(0.163-0.175)
0.172
(0.152-0.192)
0.009
IL6 rs1800795 G(C) 0.440
(0.435-0.445)
0.430
(0.412-0.448)
0.453
(0.428-0.478)
0.438
(0.430-0.446)
0.455
(0.428-0.482)
0.200
IL6 rs1800796 G(C) 0.052
(0.050-0.054)
0.055
(0.047-0.063)
0.063
(0.051-0.075)
0.051
(0.048-0.054)
0.045
(0.034-0.056)
0.108
IL10 rs1800872 C(A) 0.240
(0.236-0.244)
0.236
(0.220-0.252)
0.242
(0.221-0.263)
0.240
(0.234-0.246)
0.244
(0.221-0.267)
0.551
MTHFR rs1801133 C(T) 0.327
(0.322-0.332)
0.322
(0.305-0.339)
0.307
(0.284-0.330)
0.327
(0.320-0.334)
0.325
(0.300-0.350)
0.677
LPL rs268 A(G) 0.020
(0.019-0.021)
0.020
(0.015-0.025)
0.017
(0.011-0.023)
0.021
(0.019-0.023)
0.032
(0.022-0.042)
0.034
ACE rs4291 A(T) 0.377
(0.372-0.382)
0.377
(0.359-0.395)
0.373
(0.349-0.397)
0.379
(0.372-0.386)
0.379
(0.353-0.405)
0.879
ACE rs4343 G(A) 0.479
(0.474-0.484)
0.480
(0.462-0.498)
0.506
(0.481-0.531)
0.476
(0.468-0.484)
0.488
(0.461-0.515)
0.009
APOE rs429358 T(C) 0.145
(0.141-0.149)
0.151
(0.138-0.164)
0.117
(0.101-0.133)
0.138
(0.133-0.143)
0.182
(0.161-0.203)
<0.0001
APOE rs7412 C(T) 0.083
(0.080-0.086)
0.077
(0.067-0.087)
0.082
(0.068-0.096)
0.089
(0.085-0.093)
0.076
(0.062-0.090)
0.299
COMT rs4680 A(G) 0.466
(0.461-0.471)
0.470
(0.452-0.488)
0.484
(0.459-0.509)
0.467
(0.459-0.475)
0.421
(0.394-0.448)
0.009
VDR rs7975232 A(C) 0.483
(0.478-0.488)
0.481
(0.463-0.499)
0.491
(0.466-0.516)
0.488
(0.480-0.496)
0.468
(0.441-0.495)
0.113
VDR rs731236 T(C) 0.387
(0.382-0.392)
0.380
(0.362-0.398)
0.365
(0.341-0.389)
0.382
(0.375-0.389)
0.384
(0.358-0.410)
0.284
VDR rs1544410 G(A) 0.392
(0.387-0.397)
0.387
(0.369-0.405)
0.368
(0.344-0.392)
0.387
(0.380-0.394)
0.387
(0.361-0.413)
0.479