Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

Table 1 SNP and SNP-set associations with measures of mathematics at age 10.

Results of the tests of association of components of the mathematics composite at age 10 with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with the mathematics composite score. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. Mathematics composite at 10 = the originally associated measure of mathematics at age 10; Web total = total web-test score at age 10; Understanding Number, Non-numerical Processes and Computation and Knowledge = three components of the web-test; Teacher total = teacher rating of mathematics at age 10; Using and Applying, Number and Algebra and Shapes, space and measures = three components of the teacher rating; Cor = Pearson product-moment correlations (p-values included in italics); N = size of sample analysed; r_p= phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).

ISSN: 2730-6844