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Table 2 10-year mathematics SNP and SNP-set associations with mathematical ability at ages 7, 9 and 12.

From: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

 

Teacher mathematics at 7

Teacher mathematics at 9

Teacher mathematics at 12

Web mathematics at 12

 

Cor

N

Cor

N

Cor

N

Cor

N

rs11225308

0.019

3869

0.058**

1713

0.012

2213

0.025

3115

rs363449

0.016

3885

0.062**

1703

0.001

2223

0.018

3123

rs17278234

0.028*

3891

0.054*

1708

0.031

2227

-0.007

3132

10-SNP set

0.046**

3348

0.096**

1480

0.025

1922

0.036*

2691

43-SNP set

0.046**

3357

0.090**

1483

0.052*

1927

0.060**

2695

r p

0.594**

1979

0.633**

1632

0.566**

916

0.636**

1690

  1. Association was assessed with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with mathematics at age 10. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. Teacher mathematics at 7 = NC-based teacher-ratings of mathematical ability at age 7; Teacher mathematics at 9 = NC-based teacher-ratings of mathematical ability at age p; Web mathematics at 12 = performance on web-administered tests of mathematical ability at age 12; Teacher mathematics at 12 = NC-based teacher-ratings of mathematical ability at age 12; Cor = Pearson product moment correlations (p-values in italics); N = size of sample analysed; r p = phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).