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Table 2 The impact of the location of the QTL for the covariate - parametric and nonparametric approaches

From: Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs

 

Disease Loci (cM)

Estimate of C

95% coverage probability (%)

The Location of the Covariate's QTL

 

Parametric

Nonparametric

Parametric

Nonparametric

Parametric

Nonparametric

 
 

Ï„ 1

Ï„ 2

Ï„ 1

Ï„ 2

ASP

AGP

ASP

AGP

Ï„ 1

Ï„ 2

Ï„ 1

Ï„ 2

 
     

C11

C21

C14

C24

C11

C21

C14

C24

     

Bias

-0.02

-0.2

-0.1

1.0

0.04

0.03

-0.05

0.02

-0.02

-0.04

-0.04

0.02

95

96

96

93

 

Sample variance

4.4

3.7

4.7

5.9

0.003

0.003

0.001

0.001

0.002

0.002

0.001

0.001

     

Mean variance

4.0

4.0

4.8

5.6

             

β 1 ∧

    

0.26

-0.25

0.16

-0.08

         

p-value

    

0.03

0.05

0.52

0.82

         

Bias

0.2

-0.03

0.4

1.8

0.03

0.03

-0.05

0.02

-0.007

-0.06

-0.03

0.02

95

96

93

88

Age onset at 35 cM (Ï„1)

Sample variance

4.4

3.9

5.2

5.9

0.003

0.003

0.001

0.001

0.002

0.002

0.001

0.001

     

Mean variance

4.1

4.1

4.4

6.0

             

β 1 ∧

    

-0.04

0.04

-0.03

0.01

         

p-value

    

0.05

0.06

0.54

0.83

         

Bias

0.3

-0.3

-0.1

0.7

0.06

0.05

-0.05

0.02

-0.03

-0.04

-0.05

0.02

95

97

95

95

Co-incident 45 cM

Sample variance

6.8

5.7

9.1

8.5

0.003

0.003

0.001

0.001

0.002

0.002

0.001

0.001

     

Mean variance

6.7

6.3

8.9

9.0

             

β 1 ∧

    

-0.007

0.003

-0.002

0.006

         

p-value

    

0.96

0.95

0.94

0.95

         

Bias

0.3

-0.4

-0.8

0.6

0.003

0.05

-0.05

0.02

-0.05

-0.04

-0.06

0.010

96

96

94

95

Unlinked

Sample variance

6.8

5.5

9.6

8.6

0.005

0.003

0.001

0.001

0.002

0.002

0.001

0.001

     

Mean variance

6.7

6.3

10.3

9.3

             

β 1 ∧

    

0.96

0.002

0.006

-0.001

         

p-value

    

0.96

0.96

0.92

0.93