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Table 3 One-locus search on chromosome 1 with or without incorporation of "Maximum number of drinks in a 24 hour period"

From: Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs

 

ESTIMATE [95% CI] or (S.E.)

 

Ï„ (cM)

C

λ

 

Without a covariate

Parametric

Nonparametric

Without a covariate

Parametric

Nonparametric

Without a covariate

Parametric

Nonparametric

Using one ARP only:

         

   Full siblings

112.9

112.8

110.4

0.18

0.16

0.14

1.75

1.65

1.47

 

(6.1)

(6.5)

(7.2)

[0.04, 0.32]

[0.001,0.32]

[0.06,0.23]

[1.14,2.84]

[1.00,2.77]

[1.13,1.87]

p-value for the covariate

    

0.58

    

   Avuncular pairs

98.8

105.0

102.8

0.08

0.20

0.036

1.46

1.74

1.37

 

(12.4)

(7.8)

(6.2)

[-0.07, 0.24]

[-0.06,0.28]

[-0.10,0.23]

[0.81,2.50]

[0.79,3.56]

[0.67,2.67]

p-value for the covariate

    

0.23

    

Using both ARPs:

         

   Full siblings

   

0.18

0.17

0.14

1.70

1.61

1.44

    

[0.10, 0.26]

[0.009,0.32]

[0.045,0.23]

[1.08,2.74]

[1.02,2.70]

[1.10,1.87]

p-value for the covariate

    

0.52

    

   Avuncular pairs

   

0.064

0.10

0.034

1.66

1.77

1.28

    

[-0.0001, 0.13]

[-0.04,0.28]

[-0.07,0.18]

[0.69,3.72]

[0.85,3.55]

[0.74,2.09]

p-value for the covariate

    

0.20

    

   Common τ

113.7

110.8

109.2

      
 

(2.2)

(1.5)

(2.3)

      
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BMC Genomic Data

ISSN: 2730-6844

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