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Table 2 Genotype frequencies, minor allele frequencies (MAF) and significance of deviation from Hardy-Weinberg equilibrium (HWE) for the leptin and leptin receptor SNPs

From: Association of bovine leptin polymorphisms with energy output and energy storage traits in progeny tested Holstein-Friesian dairy cattle sires

Region GenBank Accession No. SNP BTA Position Genotype Genotype Frequency (%) MAF (%) HWE1
Receptor AJ580801 LEPR-T945M 3 85691334 C/C 0.83 0.09 0.66
      C/T 0.17   
      T/T 0.01   
Promoter AB070368 LEP-2470 4 95675400 C/C 0.75 0.13 0.25
      C/T 0.24   
      T/T 0.01   
Promoter   LEP-1457 4 95676411 A/A 0.27 0.48 1.00
      A/G 0.50   
      G/G 0.23   
Promoter   LEP-1238 4 95676628 C/C 0.14 0.37 0.57
      C/G 0.45   
      G/G 0.40   
Promoter   LEP-963 4 95676903 C/C 0.41 0.37 0.75
      C/T 0.46   
      T/T 0.14   
Coding U50365 Y7F 4 95689996 A/A 0.93 0.04 0.08
   (dsSNP rs29004487)    A/T 0.07   
      T/T 0.00   
Coding   R25C 4 95690050 C/C 0.40 0.37 0.78
   (dsSNP rs29004488)    C/T 0.47   
      T/T 0.13   
Coding   A80V 4 95691973 C/C 0.49 0.29 0.05
   (dsSNP rs29004508)    C/T 0.44   
      T/T 0.07   
  1. 1Significance of the deviation from HWE derived using a chi-square test
  2. LEP-580 and LEP-1609 were omitted from the table as they exhibit complete linkage disequilbrium with LEP-1457