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Table 2 Inflation before and after principal component correction

From: Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia

Model

λ ^ without PC adjustment

λ ^ with PC adjustment

Single-SNP tests*

1.070

1.077

Main-effects

1.101

1.059

Main+adj

1.092

1.052

Haplotype

1.064

1.037

  1. Comparison of inflation in median test statistics ( λ ^ ) for each model with and without principal components. *Single-SNP tests without PC adjustment were Cochran-Armitage trend statistics which are not able to incorporate PC adjustment. The single-SNP statistics with PC adjustment are the 1 d.f. logistic regression.
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BMC Genomic Data

ISSN: 2730-6844

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