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Table 4 NAT2 haplotypes frequency in Brazilian ethnic groups.

From: Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations

Haplotype

SNPs (HWpval)

Haplotypes (n)

 

C.N.

G191A

(0.348)

C481T

(0.613)

G590A

(1.0)

A803G

(0.303)

G857A

(0.524)

Total

Afro-Brazilians

Whites

Amerindians

A

(NAT2*4)

G

C

G

A

G

45

33

9

6

B

(NAT2*C)

G

T

G

G

G

35

6

4

3

C*

(NAT2*6A/*6B)

G

C

A

A

G

23

3

1

7

D

(NAT2*11A/*11B)

G

T

G

A

G

23

5

2

2

E

(NAT2*6I/6J)

G

C

A

A

A

11

2

1

-

F

(NAT2*7A/*7B)

G

C

G

A

A

9

1

3

-

G

(NAT2*14A/*14B/*14H)

A

C

G

A

G

8

1

1

-

H

(NAT2*12)

G

C

G

G

G

6

1

1

-

I**

(NAT2*6E)

G

T

A

A

G

5

-

-

3

J

(n.ds.)

G

T

G

A

A

4

1

-

0

K

(NAT2*12C+857A)

G

T

G

G

A

4

1

-

1

L

(NAT2*14C/*14I)

A

T

G

A

G

3

-

1

-

Slow Acetylator Haplotype

A

N

A

N

N

50

29+

6+

11+

  1. HWpval: Hardy-Weinberg equilibrium p-value for the whole sample. * and ** significant difference in frequency between Amerindians and Afro-Brazilians (χ2: 6.517; p = 0.0107 and χ2: 5.539; p = 0.0186, respectively). C, E, G, I and L are slow acetylator haplotypes and are indicated in bold. '-': Absent or with frequency < 1%. 'N': any nucleotide. '+': haplotypes with frequencies < 1% are included. C.N.: Consensus Human Arylamine N-Acetyltransferase Gene Nomenclature -http://louisville.edu/medschool/pharmacology/consensus-human-arylamine-n-acetyltransferase-gene-nomenclature; (n.d.s): SNP combination not described