Table 4 Sensitivity of each detection program when other experimental result is regarded as golden standard
From: Comparative analysis of copy number variation detection methods and database construction
Programs | Korbel[6](PE sequencing) | Kidd[7](PE sequencing) | Kidd[7]-validation | Tuzun[8](PE sequencing) | Conrad[25]**(Mendelian consistency) | Shaikh[26]** (Illumine Data) | Redon[11](Tiling array) | Perry[27](array CGH) | Conrad[28](Tiling array) | Park[29](array-CGH and massively parallel sequencing) |
|---|---|---|---|---|---|---|---|---|---|---|
PennCNV | 2.2* (2.1) | 0.5 (0.7) | 1.2 (1.5) | 5.2 (7.8) | 23.7 | 37.0 [37.1] | 1.2 (1.1) | 18.1 (22.3) | 26.2 (24.5) | 27.0 (33.0) |
Birdseye (part of Birdsuite) | 2.4 (2.4) | 0.6 (1.0) | 1.4 (2.1) | 7.7 (13.9) | 30.0 | 40.7 [44.4] | 0.8 (0.9) | 13.4 (14.0) | 23.5 (24.1) | 27.9 (36.9) |
Birdsuite | 5.5 (6.1) | 2.0 (4.3) | 5.5 (8.8) | 17.2 (24.8) | 46.1 | 51.9 [70.4] | 2.2 (3.2) | 25.6 (30.0) | 35.4 (35.9) | 42.9 (56.2) |
DNAcopy | 1.7 (1.6) | 0.4 (0.9) | 1.1 (1.9) | 5.2 (9.0) | 20.4 | 44.4 [48.1] | 0.7 (1.2) | 9.9 (11.8) | 15.3 (17.9) | 19.1 (28.7) |
CGHseg | 0.5 (0.3) | 0.1 (0.3) | 0.3 (0.6) | 1.5 (2.7) | 18.2 | 29.6 [29.6] | 0.4 (0.7) | 7.0 (6.4) | 7.7 (9.3) | 9.6 (12.6) |