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Table 3 Greater Swiss Mountain Dog association chi-square results

From: Candidate genes for idiopathic epilepsy in four dog breeds

Gene Name

Designator

H

Chi Square

P-Value

Results

*ARX

First Set

0.396

0.606

Not Significant

*CACNA1A

First Set

0.000

(---)

Monomorphic

*CACNA1A

Second Set

0.408

0.740

Not Significant

CACNA1B

First Set

0.370

0.905

Not Significant

CACNA1D

First Set

0.699

0.529

Not Significant

CACNA1E

First Set

0.675

0.953

Not Significant

CACNA1F

First Set

0.106

(---)

Low Heterozygosity

CACNA1G

First Set

0.000

(---)

Monomorphic

CACNA1G

Second Set

0.023

(---)

Low Heterozygosity

*CACNA1H

First Set

0.000

(---)

Monomorphic

*CACNA1H

Second Set

0.517

0.272

Not Significant

CACNA1I

First Set

0.483

0.449

Not Significant

#CACNA2D2

First Set

0.308

0.442

Not Significant

CACNB1

First Set

0.261

(---)

Low Heterozygosity

CACNB2

First Set

0.000

(---)

Monomorphic

CACNB3

First Set

0.322

0.718

Not Significant

*CACNB4

First Set

0.628

0.709

Not Significant

#CACNG2

First Set

0.690

0.382

Not Significant

CACNG3

First Set

0.000

(---)

Monomorphic

CACNG3

Second Set

0.591

0.527

Not Significant

CACNG4

First Set

0.298

(---)

Low Heterozygosity

CACNG6

First Set

0.482

0.323

Not Significant

CHRNA1

First Set

0.491

0.730

Not Significant

CHRNA1

Second Set

0.670

0.256

Not Significant

CHRNA1

Third Set

0.656

0.374

Not Significant

CHRNA1

Fourth Set

0.452

0.582

Not Significant

*CHRNA2

First Set

0.461

0.644

Not Significant

*CHRNA4 and KCNQ2

See KCNQ2

   

CHRNA5

First Set

0.389

0.483

Not Significant

CHRNA7

First Set

0.810

0.924

Not Significant

CHRNA9

First Set

0.615

0.875

Not Significant

CHRNB1

First Set

0.000

(---)

Monomorphic

*CHRNB2

First Set

0.333

0.055

Not Significant

*CLCN2

First Set

0.519

0.600

Not Significant

DNM1

First Set

0.139

(---)

Low Heterozygosity

DNM1

Second Set

0.364

0.799

Not Significant

DNM1

Third Set

0.500

0.834

Not Significant

DNM1

Fourth Set

0.000

(---)

Monomorphic

DNM1

Fifth Set

0.484

0.464

Not Significant

*GABRA1

First Set

0.549

0.354

Not Significant

*GABRD

First Set

0.088

(---)

Low Heterozygosity

*GABRD

Second Set

0.088

(---)

Low Heterozygosity

*GABRD

Third Set

0.081

(---)

Low Heterozygosity

*GABRG2

First Set

0.219

(---)

Low Heterozygosity

*GABRG2

Second Set

0.458

0.929

Not Significant

*KCNA1

First Set

0.171

(---)

Low Heterozygosity

KCND2

First Set

0.480

0.036

Inconclusive

KCND2

Second Set

0.729

0.155

Not Significant

KCND2

Third Set

0.124

(---)

Low Heterozygosity

*KCNQ2 and CHRNA4

First Set

0.441

0.677

Not Significant

*KCNQ3

First Set

0.382

0.904

Not Significant

KCNQ5

First Set

0.100

(---)

Low Heterozygosity

*LGI1

First Set

0.440

0.244

Not Significant

*ME2

First Set

0.219

(---)

Low Heterozygosity

*NHLRC1

Second Set

0.405

0.240

Not Significant

*SCN1A

First Set

0.749

0.706

Not Significant

*SCN1B

First Set

0.000

(---)

Monomorphic

*SCN1B

Second Set

0.000

(---)

Monomorphic

*SCN1B

Third Set

0.026

(---)

Low Heterozygosity

*SCN1B

Fourth Set

0.485

0.233

Not Significant

*SCN2A

First Set

0.686

0.767

Not Significant

SCN3A

First Set

0.000

(---)

Monomorphic

SCN3A

Second Set

0.437

0.378

Not Significant

SCN3B

First Set

0.000

(---)

Monomorphic

SCN3B

Second Set

0.000

(---)

Monomorphic

SCN8A

First Set

0.152

(---)

Low Heterozygosity

SCN8A

Second Set

0.576

0.996

Not Significant

SCN11A

First Set

0.597

0.967

Not Significant

  1. Bolded genes marked with a * indicate those associated with human IE, and bolded genes marked with a # indicate those associated with mouse models of epilepsy. The breed cohort was assembled and statistics were performed as described in Materials and Methods. "Designator" indicates each set of primers, first, second, etc., designed for that gene and used in this breed (See Additional files 1 and 2). H = heterozygosity of the marker.
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BMC Genomic Data

ISSN: 2730-6844

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