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Table 2 Estimated allele substitution effect (standard error in parenthesis) between six SNPs in the bovine GNAS domain and milk performance, somatic cell count (SCC), calving and fertility traits

From: DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits

SNP

Allele substitution

Milk yield (kg)

Milk protein yield (kg)

Milk fat content1 (%×100)

Milk protein content1 (%×100)

SCC (units×100)

Direct calving difficulty2

Maternal calving difficulty2

Gestation (days)

rs43101491

G→T

8.65

(16.56)

0.25

(0.46)

-1.25

(1.25)

-0.10

(0.61)

0.97

(1.01)

-0.51**

(0.19)

0.66**

(0.23)

-0.12

(0.12)

rs43101493

A→G

4.24

(12.05)

0.16

(0.33)

0.85

(0.91)

0.13

(0.44)

-0.97

(0.73)

0.08

(0.14)

-0.19

(0.17)

0.05

(0.09)

rs43101486

A→G

-8.94

(13.58)

-0.05

(0.38)

0.11

(1.03)

0.37

(0.50)

1.36

(0.81)

-0.16

(0.16)

0.26

(0.19)

-0.04

(0.10)

rs43101485

C→G

-2.61

(12.04)

-0.09

(0.34)

-0.85

(0.91)

-0.12

(0.44)

0.90

(0.72)

-0.12

(0.14)

0.19

(0.17)

-0.06

(0.09)

rs41694646

C→G

-34.63***

(10.48)

-0.63*

(0.29)

1.98*

(0.79)

0.94*

(0.38)

-0.60

(0.63)

-0.44***

(0.12)

0.28

(0.15)

-0.23**

(0.08)

rs41694656

A→G

20.22

(14.04)

0.63

(0.39)

-0.79

(1.06)

-0.02

(0.52)

-2.37**

0.85

0.10

(0.17)

-0.29

(0.20)

0.01

(0.11)

  1. Significance of difference from zero = P ≤ 0.10; * = P ≤ 0.05; ** = P ≤ 0.01; *** = P ≤ 0.001.
  2. 1 A value of 1, prior to multiplication by 100, equates to 1 percentage unit.
  3. 2 Expressed in standard genetic deviation units.
  4. Underlined values represent genotype-phenotype associations that have remained statistically significant (q ≤ 0.05) after adjustment for multiple testing.