Skip to main content

Table 1 Penetrance values for simulation settings

From: Combining an Evolution-guided Clustering Algorithm and Haplotype-based LRT in Family Association Studies

 

additive model

dominant model

recessive model

 

104× f0

104× f1

104× f2

104× f0

104× f1

104× f2

104× f0

104× f1

104× f2

r = 3

         

p = 0.1

71

214

357

72

217

217

98

98

294

p = 0.25

50

150

250

53

160

160

89

89

267

p = 0.5

33

100

167

40

120

120

67

67

200

r = 2.5

         

p = 0.1

77

192

308

78

195

195

99

99

246

p = 0.25

57

143

229

60

151

151

91

91

229

p = 0.5

40

100

160

47

118

118

73

73

182

r = 2

         

p = 0.1

83

167

250

84

168

168

99

99

198

p = 0.25

67

133

200

70

139

139

94

94

188

p = 0.5

50

100

150

57

114

114

80

80

160

  1. Numbers listed are scaled penetrance values (104 × f0, 104 × f1, 104 × f2) corresponding to different allele frequencies (p) and relative ratios (r) under three genetic models
  2. The prevalence K is set at 0.01