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Figure 4 | BMC Genetics

Figure 4

From: Polymorphism, selection and tandem duplication of transferrin genes in Atlantic cod (Gadus morhua) - Conserved synteny between fish monolobal and tetrapod bilobal transferrin loci

Figure 4

Ribbon representation of the calculated 3D models of the Atlantic cod transferrin forms. A. Cod Tf1 (NE variant) displaying the iron-binding N- and C-lobes each consisting of two subdomains. The conserved iron-binding residues are shown in ball and stick. B. Cod Tf2. C. Superimposition between the N- (yellow) and C-lobe (pink) of cod MTf. The C-lobe contains the four iron-binding residues Asp393, Tyr423, Tyr527 and His596, while the N-lobe is lacking the crucial Asp and His residues. D. Superimposition between cod OMP (green) and the C-lobe (brown) of cod MTf visualizing the monolobal structure of OMP, which are lacking three of the four potential iron-binding residues. E. NW variant of cod Tf1 showing the location of the 16 substituted amino acids, including eight surface residues (bold).

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