Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria

Table 3 Relationship between IL12 B 3' UTR genotypes and susceptibility to SMA

*IL-12B* 3' UTR Genotype	OR	95% CI	P	OR	95% CI	P
	SMA (Hb<5.0 g/dL)			SMA (Hb<6.0 g/dL)
AA	reference			reference
AC	1.268	0.799-2.011	0.314	1.410	0.953-2.098	0.086
CC	1.512	0.870-2.629	0.142	1.674	1.006-2.673	0.047
CC vs. AC + AA	1.335	0.816-2.185	0.249	1.370	0.880-2.133	0.826
AA vs. AC+CC	1.346	0.881-2.058	0.170	1.479	1.031-2.123	0.034

Parasitaemic children (n = 544) were categorized according to the WHO SMA definition [i.e., Hb<5.0 g/dL, with any density parasitaemia [26]] and the age- and geographically-appropriate definition of SMA [(Hb<6.0 g/dL, with any density parasitaemia [4]]. Odds Ratio (OR) and 95% confidence interval (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1, bacteremia, and sickle-cell trait (HbAS) status.

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