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Figure 2 | BMC Genetics

Figure 2

From: Normal social seeking behavior, hypoactivity and reduced exploratory range in a mouse model of Angelman syndrome

Figure 2

Three-dimensional and color coded visualizations of different aspects of exploratory behavior. Three aspects of exploratory behavior are shown under control conditions (A-I) and under test conditions, i.e. with a stranger mouse present in the cage marked with "S" (J-R). Each panel covers the entire arena. Data for Ube3am-/p-, Ube3am-/p+ and wild-type mice are shown in the left, middle and right columns respectively. All behavioral variables visualized here for qualitative comparison were also compared quantitatively (see text for details). (A-C and J-L) "Time vs. Position" plots illustrate the position of the animal over time with time increasing along the z-axis. Movement paths recorded under control and test conditions are shown in (A-C) and (J-L) respectively. Duration (i.e. the time spent at any given site along the path) is represented in color-coded maps for control and test conditions in panels (D-F) and (M-O) respectively. Sites where mice lingered for ~60 seconds or more show up as red and purple spots (the two black arrows in (D) point at two examples of such sites). The speed with which mice moved along their exploratory path is shown in color-coded maps for control and test conditions in panels (G-I) and (P-R) respectively. The color scale for duration is time in seconds. The color scale for speed is in cm/sec.

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