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Figure 3 | BMC Genetics

Figure 3

From: Normal social seeking behavior, hypoactivity and reduced exploratory range in a mouse model of Angelman syndrome

Figure 3

Various measures of exploratory activity are significantly lower in Ube3a deficient mice compared to wild-type littermates. Each bar graph shows results from control trials on the left and from test trials (with stranger present) on the right. Bar colors correspond to genotypes (Ube3am-/p- = white bar, Ube3am-/p+ = light gray, wild-type = dark gray). (A) The total length of the exploratory path was significantly shorter for Ube3a deficient compared to wild-type mice. (B) The area covered by the exploratory path was significantly smaller for Ube3a deficient compared to wild-type mice. For all three genotypes the area covered was larger during the control trial (left) than during the test trial. (C) Ube3a deficient mice spent significantly less time moving than wild-type mice during both control and test conditions. (D) The average movement speed was significantly lower for Ube3a deficient compared to wild-type mice. Symbols: * indicates a significant difference between the Ube3a deficient and the wild-type mice. ‡ indicates a significant difference between control and test conditions within the same group of mice. Error bars are SEM.

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