A genetic predisposition score for muscular endophenotypes predicts the increase in aerobic power after training: the CAREGENE study

Table 3 Genotype-phenotype association analysis for muscular subsystem gene polymorphisms and baseline aerobic power and changes after training in the CAREGENE study

Gene	Polymorphism	Allele	Frequency	VO₂pre	p-value	VO₂change	p-value	VO₂change	p-value
			N (%)	(ml/min)^a		(ml/min)^b		(%) b
AMPD1	C34T/rs17602729	CC	652 (71)	1711 ± 15	p = 0.40	396 ± 10	p = 0.11	24.8 ± 0.6	p = 0.04
		CT + TT	263 (29)	1734 ± 23		367 ± 16		22.4 ± 0.99
CNTF	G-6A/rs1800169	GG	664 (73)	1724 ± 15	p = 0.43	369 ± 9	p = 0.001	23.1 ± 0.6	p = 0.002
		GA	226 (25)	1701 ± 25		416 ± 16		25.1 ± 1.0
		AA	21 (2)	1801 ± 81		519 ± 52		33.9 ± 3.3
GR	R23K/rs6190	GG	857 (94)	1715 ± 13	p = 0.08	383 ± 9	p = 0.02	23.8 ± 0.6	p = 0.04
		GA + AA	55 (6)	1805 ± 50		464 ± 34*		28.5 ± 2.2*

AMPD1, Adenosine monophosphate deaminase; CNTF, Ciliary neurotrophic factor; GR, Glucocorticoid receptor
a. Mean ± SE, corrected for gender, age, height and weight;
b. Mean ± SE, corrected for gender, age, height, weight and baseline peakVO₂

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