Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle

BMC Genomic Data

Table 2 Association of the SNP in intron 5 of the ACSL1 gene (c.481-233A>G) with variation in intramuscular fatty acid composition and fat content

	Model without IMF as covariate							Model with IMF as covariate
Trait*	LRT	p-value	Effect allele A	SE	Effect allele G	SE	Var [%]**	LRT	p-value	Effect allele A	SE	Effect allele G	SE
Total FA [mg]*^&	6.2	0.0130	3.70	0.07	3.88	0.07		3.8	0.0507
MUFA [mg]*^&	5.9	0.0154	3.29	0.08	3.48	0.09		2.9	0.0874
n-3 FA [%]*^#	9.7	0.0018^a	0.16	0.05	0.01	0.06	11.4	5.8	0.0159	0.42	0.04	0.36	0.04
PUFA [%]*^#	7.1	0.0079^b	1.12	0.05	0.98	0.06	3.5	3.9	0.0477
n-3 LC PUFA [%]^#	6.7	0.0099^b	0.24	0.03	0.16	0.04	3.4	3.5	0.0628
C18:1trans-11 [mg]*^&	10.5	0.0012^a	1.31	0.10	1.63	0.12	6.5	8.1	0.0045^a	0.86	0.09	1.07	0.10
C22:5n-3 [%]^#	7.2	0.0071 ^b	0.16	0.02	0.11	0.03	3.6	5.9	0.0150	0.27	0.02	0.23	0.02
PUFA/SFA*	7.3	0.0069^b	-0.79	0.06	-0.94	0.07	3.6	4.2	0.0407
P/S*	6.7	0.0099^b	-1.02	0.05	-1.15	0.06	3.2	3.2	0.0758
LA/ALA*	4.9	0.0265	1.03	0.03	0.97	0.03		1.9	0.1720
IMF [%]	3.1	0.0776	1.11	0.18	1.42	0.21	1.7

*Trait data log-transformed, ^&absolute content of fatty acids (mg/100 g of skeletal muscle), ^#relative content of fatty acids (percentage of the respective fatty acid fraction relative to total fatty acid amount)
LTR: likelihood ratio test, p: significancy of allelic effects, Var: variance explained, SE: standard error, ^aq-value <0.05, ^bq-value <0.1, **% variance in the model calculated as the relative reduction of the residual variance due to including the SNP in the model [47].
Allelic effects of the ACSL1 SNP (c.481-233A>G) on different FA fractions: n-3 fatty acids (n-3 FA = C18:3n-3 + C18:4n-3 + C20:5n-3 + C22:5n-3 + C22:6n-3), poly-unsaturated fatty acids (PUFA = n-3 FA + n-6 FA [C18:2n-6 + C18:3n-6 + C20:2n-6 + C20:3n-6 + C20:4n-6 + C22:2n-6 + C22:4n-6]), n-3 long-chain PUFA (n-3 LC-PUFA = C20:3n-3 + C22:6n-3 + C22:5n-3 + C20:5n-3), total FA, mono-unsaturated fatty acids (MUFA), docosapentaenoic fatty acid (DPA, C22:5n-3), trans vaccenic acid (TVA, C18:1trans-11) and the ratios: PUFA/SFA (saturated fatty acids = C12:0 + C14:0 + C16:0 + C17:0 + C18:0 + C20:0 + C24:0), P/S (C18:2 n-6 + C18:3 n-3/C14:0 + C16:0 + C18:0), LA/ALA (C18:2 n-6/C18:3 n-3), and the intramuscular fat content (IMF).

ISSN: 2730-6844