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Table 1 Synthetic lethal or slow growth interactions with mcm2 AA

From: Mcm2 phosphorylation and the response to replicative stress

Gene

ORF

Function

GO

growth

chk1Δ

YBR274W

Checkpoint Kinase

1,2,5

lethal

ctf4Δ

YPR135W

Sister Chromatid Cohesion

1,2

lethal

sod1Δ

YJR104C

Response to oxygen radicals

1,6,8

slow

bud23Δ

YCR047C

Bud site selection

2,3,4

lethal

pep3Δ

YLR148W

Vesicular docking/Vacuolar biogenesis

3,8

lethal

skn1Δ

YGR143W

Sphingolipid biosynthesis

7,8

slow

img1Δ

YCR046C

Mitochondrial genome maintenance

9

lethal

vma13Δ

YPR036W

Subunit of Vacuolar ATPase

10

lethal

  1. Genes are grouped by their GO terms as annotated in the Saccharomyces cerevisiae database [37]. Gene ontology: (1) Response to cell stress/chemical stimuli (2) cell cycle, (3) transport, (4) RNA metabolic process, (5) signalling process/protein modification process, (6) transcription, (7) carbohydrate metabolic process, (8) cell wall, membrane, & vesicle mediated transport, (9) mitochondrial organization, and (10) other.