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Table 3 Phenotypes of deletions that suppress the caffeine sensitivity of mcm2 AA

From: Mcm2 phosphorylation and the response to replicative stress

  Sensitivities Suppression of mcm2 AA
mutation caff MMS 5-FU HU MMS 5-FU HU RFA foci mutation rate
srs2Δ R S S S - - + + +
mcr1Δ R R S S - + + ND ND
tof1Δ S S R S + + +/− - -
rad9Δ S S R S - - + + +
rad2Δ S S S S + + + + -
pdr15Δ S R S R + + + + +
rds2Δ R S S S + +/− + ND ND
yhp1Δ R+ R+ R+ R + + + ND ND
mbp1Δ S R R S + + + + -
ume6Δ S R R R + + - + -
hrd1Δ S S R S + + + + +
ssm4Δ R+ R R S + + + + +
pac10Δ R S S S + + + ND ND
sip18Δ S S R R+ + + + + +
rpl8bΔ R+ S S S + + + + +
ett1Δ R R+ R R+ + + + ND ND
  1. The sensitivities of the deletion strains (with wild type MCM2) to each drug is indicated by “R” for growth similar to wild type, “S” for growth slower than wild type or “R+” for better than wild type growth. For suppression of the phenotypes associated with mcm2AA, “-“indicates no suppression, “+” indicates suppression, “E” indicates epistasis and “ND” indicates that the test was not performed on that strain.