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# Table 1 Used values forα g ,β g (g = 0,1,2),c, and z

Risk model   Risk scenario Constant values αg, βg ( g = 0,1,2) Constant values c, z
Genetic model High risk $α 0 = 2 3 · α 1 , α 1 =2.5, α 2 = 4 3 · α 1$ z = 0.886
β0 = β1 = β2 = 0
Low risk $α 0 = 2 3 · α 1 , α 1 =1.25, α 2 = 4 3 · α 1$ z = 0.390
β0 = β1 = β2 = 0
Environmental model High risk α0 = α1 = α2 = 7.5, z = 0.200
β0 = β1 = β2 = −0.15,
Low risk α0 = α1 = α2 = 3.75, z = 0.200
Risk models by Amato et al. [14]    β0 = β1 = β2 = −0.075,
Additive model High risk $α 0 = 2 3 · α 1 , α 1 =7.5, α 2 = 4 3 · α 1$, z = 0.177
β0 = β1 = β2 = −0.15,
Low risk $α 0 = 2 3 · α 1 , α 1 =3.75, α 2 = 4 3 · α 1$, z = 0.178
β0 = β1 = β2 = −0.075,
Interaction model High risk α0 = α1 = α2 = 7.5, z = 0.171
β0 = 2 · β1, β1 = −0.15, β2 = 0.5·β1,
Low risk α0 = α1 = α2 = 3.75, z = 0.169
β0 = 2 · β1, β1 = −0.075, β2 = 0.5 · β1,
Model 1 High risk (r = 0.150)   c = 0.05, z = 0.254
Low risk (r = 0.075)
Risk model representing a masking effect of the genetic factor Model 2 High risk (r = 0.150)   c = 0.05, z = 0.286
Low risk (r = 0.075)
Model 3 High risk (r = 0.150)   c = 0.075, z = 0.631
Low risk (r = 0.075)
Model 4 High risk (r = 0.150)   c = 0.075, z = 0.964
Low risk (r = 0.075)
1. Constant values α g , β g (g = 0,1,2) c, and z used to determine the penetrance functions (minor allele frequency 30%).