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Table 2 Comparative SNP density based on sequencing studies of the human and the rhesus macaque

From: The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human

Genome

Technology used

SNPs/Kb

Venter

Sanger method

1.41*

Watson

454 Sequencing System (Roche)

1.46*

Chinese (YH)

Genome Analyzer (Illumina)

1.35*

African (NA18507)

Genome Analyzer (Illumina)

1.58*

African (NA18507)

SOLiD system (Applied Biosystems)

1.69*

Korean (SJK)

Genome Analyzer (Illumina)

1.50*

Korean (AK1)

Genome Analyzer (Illumina)

1.51*

Proband (III-4)

SOLiD system (Applied Biosystems)

1.50*

CEU,YRI

Genome Analyzer, SOLiD, 454

1.21-1.48**

Humans, in this study

Genome Analyzer (Illumina)

1.07(0.97-1.26)

Macaques, in this study

Genome Analyzer (Illumina)

2.82(1.88-3.71)

  1. *The SNP number was from Lupski et al. 2010 [19] and SNPs/Kb was calculated based on the total SNPs reported, an estimated size of 2.85 x 109 for the sequenced human genome and an estimate that 80% of the genome was accessible, for example due to mappability [17].
  2. **Based on SNPs detected and accessible genome size from the high coverage Pilot Trios data of the 1000 Genomes Project [17].