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Table 2 Power for all tests in simulated data of scenario B, no common SNPs effect, effects of RVs are in the same directions

From: Weighted selective collapsing strategy for detecting rare and common variants in genetic association study

OR 1.3 1.6 1.9 2.2 2.5 2.8 3.1
R ind 0.227 0.376 0.522 0.63 0.737 0.81 0.851
R sum 0.245 0.424 0.57 0.67 0.778 0.846 0.888
B ind 0.129 0.204 0.318 0.419 0.522 0.623 0.698
B sum 0.147 0.243 0.343 0.47 0.565 0.674 0.751
R i n d S C 0.295 0.42 0.589 0.726 0.834 0.884 0.954
R s u m S C 0.298 0.425 0.588 0.731 0.834 0.894 0.946
B wSum 0.302 0.474 0.631 0.71 0.81 0.875 0.931
B wOR 0.09 0.17 0.226 0.295 0.416 0.408 0.58
B KML 0.044 0.054 0.057 0.067 0.08 0.074 0.078
B SSU 0.042 0.049 0.053 0.062 0.075 0.071 0.07
B SSUw 0.136 0.257 0.386 0.592 0.706 0.814 0.866
B aSSU 0.074 0.106 0.197 0.219 0.275 0.324 0.351
B aSSUw 0.161 0.243 0.378 0.504 0.691 0.755 0.823
B aSSUOrd 0.234 0.325 0.468 0.628 0.738 0.849 0.877
B aSSUwOrd 0.211 0.293 0.462 0.629 0.793 0.847 0.896
B wSCd 0.201 0.34 0.445 0.586 0.734 0.825 0.885
B wSC 0.316 0.509 0.654 0.775 0.892 0.927 0.97
  1. There is a customized LD structure among common variants and among rare variants.
  2. Randomly selected eight rare variants are casual variants. Others are non- casual variants. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2,3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly those in Table 1.