Skip to main content

Advertisement

Table 3 Power for all tests in simulated data of scenario C weak common SNPs effect, effects of RVs are in the same direction

From: Weighted selective collapsing strategy for detecting rare and common variants in genetic association study

OR 1.3 1.6 1.9 2.2 2.5 2.8 3.1
R ind 0.237 0.394 0.472 0.6 0.715 0.785 0.843
R sum 0.247 0.418 0.543 0.636 0.747 0.811 0.869
C bon 0.163 0.157 0.144 0.164 0.174 0.191 0.193
C logit 0.195 0.199 0.193 0.207 0.212 0.228 0.238
B ind 0.278 0.364 0.436 0.517 0.618 0.677 0.76
B sum 0.298 0.384 0.461 0.562 0.668 0.735 0.795
R i n d S C 0.236 0.43 0.565 0.702 0.781 0.888 0.91
R s u m S C 0.238 0.446 0.605 0.705 0.815 0.892 0.92
B wSum 0.341 0.534 0.658 0.703 0.846 0.87 0.911
B wOR 0.253 0.312 0.344 0.475 0.456 0.582 0.648
B KML 0.167 0.186 0.186 0.19 0.204 0.199 0.2
B SSU 0.165 0.179 0.179 0.181 0.192 0.192 0.188
B SSUw 0.203 0.334 0.458 0.61 0.716 0.808 0.861
B aSSU 0.168 0.215 0.235 0.28 0.303 0.34 0.383
B aSSUw 0.181 0.346 0.399 0.546 0.64 0.755 0.819
B aSSUOrd 0.163 0.293 0.376 0.571 0.592 0.733 0.798
B aSSUwOrd 0.238 0.367 0.506 0.663 0.732 0.847 0.89
B wSCd 0.21 0.395 0.484 0.625 0.661 0.822 0.848
B wSC 0.344 0.538 0.631 0.778 0.85 0.935 0.954
  1. There is customized LD structure among common variants and among rare variants.
  2. The OR for underlying common SNP is 1.5. Genetic effect parameter OR for eight rare variants is listed in the table. If OR is 2, Odds Ratio = (2, 2, 2, 2, 3, 3, 3, 3) for eight casual rare variants. Notations of tests are defined similarly as those in Table 1.