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Table 1 Relative expression patterns of GWAS diabetes genes in chow fed mice

From: Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets

 

Isl

Brain

Hypo

P-AT

BAT

Liver

SkM

Hrt

St

SI

LI

Lung

Kid

Spl

Ov

Ut

Thy

Adam30

NE

Low

NE

Avg

NE

NE

Avg

Avg

Avg

NE

NE

NE

NE

Avg

NE

NE

Avg

Adamts9

Low

Low

Avg

Avg

Avg

Avg

NE

Avg

Avg

NE

Avg

Avg

Avg

Avg

High

High

Avg

Camk1d

Avg

Avg

Avg

Avg

Avg

Avg

Low

Avg

Avg

NE

High

NE

Avg

Avg

Avg

Avg

High

Cdc123

Avg

Avg

Avg

Avg

Avg

Avg

Low

Avg

Avg

NE

Avg

Low

Avg

Avg

High

Avg

Avg

Cdkal1

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Low

Avg

Avg

Avg

Avg

Avg

Cdkn2a (Arf)

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Avg

Cdkn2a

NE

NE

NE

Avg

Avg

NE

NE

NE

NE

NE

Avg

NE

Avg

Avg

NE

NE

Low

Cdkn2b

High

Avg

Avg

Avg

Avg

Avg

NT

Avg

NT

High

NT

NT

Avg

NT

High

Low

Low

Ext2

Low

Avg

Avg

Avg

Avg

Avg

Low

Avg

Avg

Avg

Avg

Low

Avg

Avg

High

Avg

Avg

Hhex

Low

Avg

Avg

Avg

Avg

High

Low

Avg

Low

Low

Avg

Low

Avg

High

Avg

High

Avg

Ide

Avg

Avg

Avg

Avg

High

Avg

NT

Avg

NT

Avg

NT

NT

NT

NT

High

Low

Low

Jazf1

Avg

Avg

Avg

Avg

High

NE

NE

Avg

Low

Low

Avg

Low

Low

Low

Avg

High

Avg

Lgr5

NE

High

Avg

Avg

Low

Avg

Low

Avg

Avg

NE

Avg

Low

NE

Avg

High

High

Avg

Thada

Avg

Avg

Avg

Avg

Avg

Avg

NE

Avg

Avg

NE

Avg

Low

Avg

Avg

High

Avg

Avg

Tspan8

Low

Low

Low

Avg

Avg

Low

Low

Avg

High

NE

High

NE

Avg

High

Avg

High

Low

  1. Expression levels are relative within a gene, but comparisons between genes cannot be made. Isl = islets, Hypo = hypothalamus, P-AT = parametrial white adipose tissue, BAT = brown adipose tissue, SkM = skeletal muscle (soleus),Hrt = heart, St = stomach, SI = small intestine (duodenum), LI = large intestine (distal), Kid = kidney, Spl = spleen, Ov = ovary, Ut = uterus, Thy = thymus. NE = not expressed, Ct values within 2 cycles of negative control; avg. = average expression (within 5-fold (2.3 cycles) of average expression across all tissues); high = >5 fold higher (Ct values >2.3 cycles lower) than average expression; low = >5 fold lower (Ct value >2.3 cycles higher) than average expression. NT = not tested.