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Table 3 Individual TagSNP association analysis with BMI adjusted by age and gender under an additive genetic model in Pizarra, Hortega and the pooled analysis

From: Impact of obesity-related genes in Spanish population

       

BMI

Gene

SNP

A1

MAF

Population

Prior statistical power

N*

Beta

Standard error

STAT**

P

FTO

rs9939609*

A

0.398

PIZARRA

32.77

848

0.875

0.23

3.79

0.0001573

   

0.435

HORTEGA

66.65

1345

0.1348

0.15

0.90

0.368

   

0.420

POOLED

77.88

2215

0.2976

0.13

2.19

0.0287

 

rs8044769

T

0.463

PIZARRA

30.96

848

−0.582

0.23

−2.54

0.0112

   

0.455

HORTEGA

62.61

1331

−0.1019

0.15

−0.68

0.495

   

0.458

POOLED

73.98

2198

−0.257

0.13

−1.90

0.0571

 

rs7190492

A

0.328

PIZARRA

5.06

845

−0.559

0.23

−2.34

0.0192

   

0.337

HORTEGA

5.16

1346

0.2065

0.16

1.29

0.195

   

0.333

POOLED

5.21

2213

−0.07336

0.14

−0.51

0.6076

 

rs6499640

G

0.376

PIZARRA

5.01

847

0.336

0.23

1.43

0.1511

   

0.381

HORTEGA

5.02

1347

0.09312

0.15

0.60

0.543

   

0.379

POOLED

5.02

2216

0.2335

0.13

1.69

0.0911

MC4R

rs17782313*

C

0.199

PIZARRA

9.69

848

0.575

0.28

1.98

0.0478

   

0.191

HORTEGA

16.33

1348

0.1167

0.19

0.60

0.544

   

0.195

POOLED

20.23

2218

0.3111

0.17

1.80

0.0716

MTCH2

rs10838738

G

0.352

PIZARRA

5.80

845

0.453

0.24

1.88

0.0603

   

0.353

HORTEGA

6.98

1348

0.0972

0.15

0.62

0.536

   

0.353

POOLED

7.61

2215

0.1698

0.14

1.19

0.2318

NEGR1

rs3101336

A

0.375

PIZARRA

7.89

848

−0.084

0.24

−0.34

0.7277

   

0.343

HORTEGA

11.89

1348

−0.403

0.15

−2.64

0.0083

   

0.355

POOLED

14.23

2210

−0.1586

0.14

−1.13

0.2561

ATXN2L

rs8049439

C

0.375

PIZARRA

8.87

848

−0.139

0.23

−0.58

0.5576

   

0.338

HORTEGA

14.15

1344

0.3292

0.15

2.13

0.0331

   

0.353

POOLED

17.35

2209

0.1715

0.14

1.22

0.2198

HTR2C

rs3813929

T

0.157

PIZARRA

10.16

847

−0.406

0.35

−1.16

0.2455

   

0.182

HORTEGA

19.46

1342

−0.4365

0.23

−1.89

0.0577

   

0.172

POOLED

23.29

2211

−0.5551

0.20

−2.68

0.0073

ADRB2

rs12654778

A

0.388

PIZARRA

3 5.35

848

0.271

0.23

1.16

0.2452

   

0.380

HORTEGA

69.22

1347

−0.1452

0.15

−0.95

0.339

   

0.382

POOLED

80.65

2217

0.01463

0.13

0.10

0.9152

SEC16B

rs10913469

C

0.142

PIZARRA

9.33

848

0.392

0.32

1.21

0.2266

   

0.152

HORTEGA

16.43

1347

−0.1609

0.20

−0.78

0.432

   

0.148

POOLED

19.78

2216

0.00939

0.18

0.05

0.96

TMEM18

rs4854344

G

0.172

PIZARRA

15.26

847

−0.198

0.30

−0.64

0.5173

   

0.169

HORTEGA

30.08

1348

−0.3012

0.20

−1.48

0.138

   

0.170

POOLED

37.86

2217

−0.243

0.18

−1.33

0.1815

INSIG2

rs7566605

C

0.327

PIZARRA

13.68

846

0.101

0.24

0.41

0.676

   

0.321

HORTEGA

26.42

1348

−0.0301

0.16

−0.18

0.8514

   

0.322

POOLED

33.12

2216

0.1152

0.14

0.79

0.4265

ADIPOQ

rs17300539

A

0.126

PIZARRA

7.59

844

−0.072

0.33

−0.21

0.8298

   

0.118

HORTEGA

11.08

1348

0.1146

0.22

0.51

0.6082

   

0.120

POOLED

13.15

2214

0.0818

0.20

0.40

0.6838

 

rs3774261

A

0.495

PIZARRA

10.96

844

−0.036

0.22

−0.16

0.8727

   

0.461

HORTEGA

19.84

1346

−0.0549

0.15

−0.36

0.7138

   

0.473

POOLED

26.42

2210

0.0609

0.13

0.45

0.6503

ETV5

rs7647305

T

0.205

PIZARRA

10.76

838

0.022

0.28

0.079

0.9364

   

0.215

HORTEGA

19.82

1325

0.2402

0.18

1.30

0.1927

   

0.213

POOLED

24.39

2175

0.2106

0.16

1.26

0.2077

GNPDA2

rs10938397

G

0.440

PIZARRA

11.60

848

−0.338

0.22

−1.52

0.1278

   

0.455

HORTEGA

21.56

1348

−0.048

0.15

−0.32

0.7492

   

0.449

POOLED

26.80

2218

−0.1687

0.13

−1.26

0.2078

PRL

rs4712652

A

0.453

PIZARRA

5.28

828

0.203

0.23

0.87

0.3846

  

G

0.487

HORTEGA

5.69

1326

0.0367

0.15

0.24

0.8056

  

A

0.489

POOLED

5.91

2175

−0.115

0.13

−0.84

0.3976

PTER

rs10508503

T

0.093

PIZARRA

5.10

841

−0.119

0.39

−0.30

0.7617

   

0.112

HORTEGA

5.27

1315

−0.279

0.23

−1.21

0.2238

   

0.105

POOLED

5.34

2174

−0.3695

0.21

−1.71

0.0866

BDNF

rs925946

T

0.282

PIZARRA

10.40

848

0.128

0.24

0.51

0.6046

   

0.266

HORTEGA

17.97

1348

−0.071

0.16

−0.44

0.6578

   

0.272

POOLED

22.37

2215

0.0795

0.14

0.54

0.5855

 

rs10501087

C

0.253

PIZARRA

10.01

845

0.033

0.26

0.12

0.8988

   

0.231

HORTEGA

16.77

1348

0.0875

0.17

0.49

0.6231

   

0.240

POOLED

20.96

2214

0.1472

0.15

0.93

0.3493

FAIM2

rs7138803

A

0.352

PIZARRA

7.38

844

0.155

0.24

0.65

0.5159

   

0.352

HORTEGA

10.92

1348

−0.0643

0.15

−0.42

0.675

   

0.351

POOLED

12.81

2214

0.0513

0.14

0.36

0.7129

MAF

rs1424233

A

0.483

PIZARRA

5.29

846

−0.192

0.23

−0.83

0.4074

  

G

0.499

HORTEGA

5.70

1348

0.2336

0.14

1.57

0.1158

  

A

0.495

POOLED

5.92

2216

−0.2422

0.13

−1.79

0.0725

NPC1

rs1805081

G

0.329

PIZARRA

5.25

845

−0.014

0.24

−0.05

0.9553

   

0.352

HORTEGA

5.64

1345

0.0046

0.15

0.03

0.9758

   

0.344

POOLED

5.83

2212

−0.0463

0.14

−0.32

0.7432

KCTD15

rs11084753

A

0.395

PIZARRA

5.62

846

0.093

0.23

0.39

0.6897

   

0.352

HORTEGA

6.44

1343

−0.1562

0.15

−1.01

0.31

   

0.367

POOLED

6.94

2210

0.0573

0.13

0.41

0.6781

CTNNBL1

rs6013029

T

0.091

PIZARRA

5.79

847

0.014

0.39

0.036

0.9708

   

0.066

HORTEGA

6.44

1348

−0.1522

0.30

−0.50

0.6133

   

0.076

POOLED

7.16

2216

0.1139

0.25

0.44

0.6547

  1. A1: minor allele, *Number of non-missing individuals included in the analysis (top) and frequency of the haplotype in the sample (bottom); **t statistic coefficient; p-values are not corrected for multiple testing; Bold type indicates significant association after Bonferroni correction. **The SNPs, rs4788102 in the SH2B1 and rs4074134 of the BDNFOS genes are not included because are in high LD with the SNPs, rs8049439 of the ATXN2L gene (r2 0.94) and rs10501087of the BDNF gene (r2 0.95), respectively.