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Table 3 Individual TagSNP association analysis with BMI adjusted by age and gender under an additive genetic model in Pizarra, Hortega and the pooled analysis

From: Impact of obesity-related genes in Spanish population

        BMI
Gene SNP A1 MAF Population Prior statistical power N* Beta Standard error STAT** P
FTO rs9939609* A 0.398 PIZARRA 32.77 848 0.875 0.23 3.79 0.0001573
    0.435 HORTEGA 66.65 1345 0.1348 0.15 0.90 0.368
    0.420 POOLED 77.88 2215 0.2976 0.13 2.19 0.0287
  rs8044769 T 0.463 PIZARRA 30.96 848 −0.582 0.23 −2.54 0.0112
    0.455 HORTEGA 62.61 1331 −0.1019 0.15 −0.68 0.495
    0.458 POOLED 73.98 2198 −0.257 0.13 −1.90 0.0571
  rs7190492 A 0.328 PIZARRA 5.06 845 −0.559 0.23 −2.34 0.0192
    0.337 HORTEGA 5.16 1346 0.2065 0.16 1.29 0.195
    0.333 POOLED 5.21 2213 −0.07336 0.14 −0.51 0.6076
  rs6499640 G 0.376 PIZARRA 5.01 847 0.336 0.23 1.43 0.1511
    0.381 HORTEGA 5.02 1347 0.09312 0.15 0.60 0.543
    0.379 POOLED 5.02 2216 0.2335 0.13 1.69 0.0911
MC4R rs17782313* C 0.199 PIZARRA 9.69 848 0.575 0.28 1.98 0.0478
    0.191 HORTEGA 16.33 1348 0.1167 0.19 0.60 0.544
    0.195 POOLED 20.23 2218 0.3111 0.17 1.80 0.0716
MTCH2 rs10838738 G 0.352 PIZARRA 5.80 845 0.453 0.24 1.88 0.0603
    0.353 HORTEGA 6.98 1348 0.0972 0.15 0.62 0.536
    0.353 POOLED 7.61 2215 0.1698 0.14 1.19 0.2318
NEGR1 rs3101336 A 0.375 PIZARRA 7.89 848 −0.084 0.24 −0.34 0.7277
    0.343 HORTEGA 11.89 1348 −0.403 0.15 −2.64 0.0083
    0.355 POOLED 14.23 2210 −0.1586 0.14 −1.13 0.2561
ATXN2L rs8049439 C 0.375 PIZARRA 8.87 848 −0.139 0.23 −0.58 0.5576
    0.338 HORTEGA 14.15 1344 0.3292 0.15 2.13 0.0331
    0.353 POOLED 17.35 2209 0.1715 0.14 1.22 0.2198
HTR2C rs3813929 T 0.157 PIZARRA 10.16 847 −0.406 0.35 −1.16 0.2455
    0.182 HORTEGA 19.46 1342 −0.4365 0.23 −1.89 0.0577
    0.172 POOLED 23.29 2211 −0.5551 0.20 −2.68 0.0073
ADRB2 rs12654778 A 0.388 PIZARRA 3 5.35 848 0.271 0.23 1.16 0.2452
    0.380 HORTEGA 69.22 1347 −0.1452 0.15 −0.95 0.339
    0.382 POOLED 80.65 2217 0.01463 0.13 0.10 0.9152
SEC16B rs10913469 C 0.142 PIZARRA 9.33 848 0.392 0.32 1.21 0.2266
    0.152 HORTEGA 16.43 1347 −0.1609 0.20 −0.78 0.432
    0.148 POOLED 19.78 2216 0.00939 0.18 0.05 0.96
TMEM18 rs4854344 G 0.172 PIZARRA 15.26 847 −0.198 0.30 −0.64 0.5173
    0.169 HORTEGA 30.08 1348 −0.3012 0.20 −1.48 0.138
    0.170 POOLED 37.86 2217 −0.243 0.18 −1.33 0.1815
INSIG2 rs7566605 C 0.327 PIZARRA 13.68 846 0.101 0.24 0.41 0.676
    0.321 HORTEGA 26.42 1348 −0.0301 0.16 −0.18 0.8514
    0.322 POOLED 33.12 2216 0.1152 0.14 0.79 0.4265
ADIPOQ rs17300539 A 0.126 PIZARRA 7.59 844 −0.072 0.33 −0.21 0.8298
    0.118 HORTEGA 11.08 1348 0.1146 0.22 0.51 0.6082
    0.120 POOLED 13.15 2214 0.0818 0.20 0.40 0.6838
  rs3774261 A 0.495 PIZARRA 10.96 844 −0.036 0.22 −0.16 0.8727
    0.461 HORTEGA 19.84 1346 −0.0549 0.15 −0.36 0.7138
    0.473 POOLED 26.42 2210 0.0609 0.13 0.45 0.6503
ETV5 rs7647305 T 0.205 PIZARRA 10.76 838 0.022 0.28 0.079 0.9364
    0.215 HORTEGA 19.82 1325 0.2402 0.18 1.30 0.1927
    0.213 POOLED 24.39 2175 0.2106 0.16 1.26 0.2077
GNPDA2 rs10938397 G 0.440 PIZARRA 11.60 848 −0.338 0.22 −1.52 0.1278
    0.455 HORTEGA 21.56 1348 −0.048 0.15 −0.32 0.7492
    0.449 POOLED 26.80 2218 −0.1687 0.13 −1.26 0.2078
PRL rs4712652 A 0.453 PIZARRA 5.28 828 0.203 0.23 0.87 0.3846
   G 0.487 HORTEGA 5.69 1326 0.0367 0.15 0.24 0.8056
   A 0.489 POOLED 5.91 2175 −0.115 0.13 −0.84 0.3976
PTER rs10508503 T 0.093 PIZARRA 5.10 841 −0.119 0.39 −0.30 0.7617
    0.112 HORTEGA 5.27 1315 −0.279 0.23 −1.21 0.2238
    0.105 POOLED 5.34 2174 −0.3695 0.21 −1.71 0.0866
BDNF rs925946 T 0.282 PIZARRA 10.40 848 0.128 0.24 0.51 0.6046
    0.266 HORTEGA 17.97 1348 −0.071 0.16 −0.44 0.6578
    0.272 POOLED 22.37 2215 0.0795 0.14 0.54 0.5855
  rs10501087 C 0.253 PIZARRA 10.01 845 0.033 0.26 0.12 0.8988
    0.231 HORTEGA 16.77 1348 0.0875 0.17 0.49 0.6231
    0.240 POOLED 20.96 2214 0.1472 0.15 0.93 0.3493
FAIM2 rs7138803 A 0.352 PIZARRA 7.38 844 0.155 0.24 0.65 0.5159
    0.352 HORTEGA 10.92 1348 −0.0643 0.15 −0.42 0.675
    0.351 POOLED 12.81 2214 0.0513 0.14 0.36 0.7129
MAF rs1424233 A 0.483 PIZARRA 5.29 846 −0.192 0.23 −0.83 0.4074
   G 0.499 HORTEGA 5.70 1348 0.2336 0.14 1.57 0.1158
   A 0.495 POOLED 5.92 2216 −0.2422 0.13 −1.79 0.0725
NPC1 rs1805081 G 0.329 PIZARRA 5.25 845 −0.014 0.24 −0.05 0.9553
    0.352 HORTEGA 5.64 1345 0.0046 0.15 0.03 0.9758
    0.344 POOLED 5.83 2212 −0.0463 0.14 −0.32 0.7432
KCTD15 rs11084753 A 0.395 PIZARRA 5.62 846 0.093 0.23 0.39 0.6897
    0.352 HORTEGA 6.44 1343 −0.1562 0.15 −1.01 0.31
    0.367 POOLED 6.94 2210 0.0573 0.13 0.41 0.6781
CTNNBL1 rs6013029 T 0.091 PIZARRA 5.79 847 0.014 0.39 0.036 0.9708
    0.066 HORTEGA 6.44 1348 −0.1522 0.30 −0.50 0.6133
    0.076 POOLED 7.16 2216 0.1139 0.25 0.44 0.6547
  1. A1: minor allele, *Number of non-missing individuals included in the analysis (top) and frequency of the haplotype in the sample (bottom); **t statistic coefficient; p-values are not corrected for multiple testing; Bold type indicates significant association after Bonferroni correction. **The SNPs, rs4788102 in the SH2B1 and rs4074134 of the BDNFOS genes are not included because are in high LD with the SNPs, rs8049439 of the ATXN2L gene (r2 0.94) and rs10501087of the BDNF gene (r2 0.95), respectively.