Table 1 Clinical characteristics of study subjects stratified by Wnt16a insertion carriers versus non-carriers
From: Carriers of a novel frame-shift insertion in WNT16a possess elevatedpancreatic expression of TCF7L2
Trait | Non carrier | Carrier | Pvalue |
|---|---|---|---|
Number | 1377 | 657 | - |
% Males | 52 | 51 | - |
Age (yrs) | 53.4 ± 12.9 | 51.7 ± 12.1 | 0.004 |
Obesity | |||
BMI (kg/m2) | 26.8 ± 4.9 | 26.8 ± 5.1 | 0.930 |
Weight (kg) | 69.8 ± 14.0 | 70.0 ± 14.3 | 0.811 |
Waist (cm) | 93.6 ± 12.2 | 93.4 ± 12.0 | 0.704 |
WHR | 0.95 ± 0.08 | 0.95 ± 0.08 | 0.242 |
Metabolic | |||
Fasting Blood Glucose mg/dL | 120.7 ± 45.4 | 121.5 ± 45.4 | 0.736 |
Insulin (μIU/mL) | 6.9 (6.6-7.3) | 7.5 (7.0-8.1) | 0.081 |
HOMA-IR | 2.0 (1.9-2.2) | 2.2 (2.1-2.4) | 0.059 |
C-peptide pg/mL | 519.5 (473.7-569.7) | 602.8 (525.6-691.4) | 0.078 |
Inflammation | |||
TNFα pg/mL | 7.9 (7.4-8.5) | 9.2 (8.2-10.2) | 0.029 |
MCP1 pg/mL | 315.5 (296.7-335.6) | 326.5 (297.9-357.8) | 0.541 |
Lipid | |||
Triglyceride mg/dL | 149.0 ± 82.3 | 151.5 ± 85.9 | 0.542 |
Total Cholesterol mg/dL | 173.8 ± 52.9 | 179.2 ± 49.9 | 0.038 |
HDL-C mg/dL | 37.2 ± 14.7 | 37.9 ± 14.2 | 0.292 |
LDL-C mg/dL | 102.1 ± 40.0 | 104.9 ± 38.3 | 0.143 |