Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study

Table 3 Loci with evidence of heterogeneity by sex (P_het < 0.001) in PAGE European Americans

Gene	SNP	Coded Allele	Pheno-type	Males				Females				$P_{comb}^{†}$	$P_{diff}^{‡}$	$P_{het}^{§}$
				CAF	β (SE)	P	N	CAF	β (SE)	P	N
APOA5/BUD13 cluster	rs28927680	C	ln(TG)	0.07	0.13 (0.02)	5.4E-17	9136	0.07	0.04 (0.01)	3.77E-04	15137	2.3E-14	9.8E-19	7.4E-07
APOA5/BUD13 cluster	rs3135506	C	ln(TG)	0.06	0.16 (0.02)	1.9E-22	8173	0.06	0.09 (0.01)	1.16E-13	9588	8.4E-32	2.3E-33	4.3E-04
PLTP	rs7679	T	HDL	0.82	0.10 (0.30)	7.3E-01	5439	0.82	1.68 (0.37)	6.27E-06	6089	1.9E-03	3.5E-05	9.9E-04
HMGCR	rs12654264	A	LDL	0.62	−4.03 (0.54)	8.3E-14	8088	0.62	−1.17 (0.42)	5.98E-03	12424	1.2E-11	1.7E-14	3.1E-05

^*Abbreviations: CAF = coded allele frequency; SE = standard error.
^†P-value for SNP-phenotype association in the sex-combined meta-analysis, not allowing for heterogeneity by sex.
^‡P-value for SNP-phenotype association in the sex-combined meta-analysis, allowing for different effects by sex.
^§P-value for heterogeneity by sex.

ISSN: 2730-6844