Skip to main content

Table 3 Loci with evidence of heterogeneity by sex (P het < 0.001) in PAGE European Americans

From: Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study

Gene SNP Coded Allele Pheno-type Males Females P comb P diff P het §
     CAF β (SE) P N CAF β (SE) P N    
APOA5/BUD13 cluster rs28927680 C ln(TG) 0.07 0.13 (0.02) 5.4E-17 9136 0.07 0.04 (0.01) 3.77E-04 15137 2.3E-14 9.8E-19 7.4E-07
rs3135506 C ln(TG) 0.06 0.16 (0.02) 1.9E-22 8173 0.06 0.09 (0.01) 1.16E-13 9588 8.4E-32 2.3E-33 4.3E-04
PLTP rs7679 T HDL 0.82 0.10 (0.30) 7.3E-01 5439 0.82 1.68 (0.37) 6.27E-06 6089 1.9E-03 3.5E-05 9.9E-04
HMGCR rs12654264 A LDL 0.62 −4.03 (0.54) 8.3E-14 8088 0.62 −1.17 (0.42) 5.98E-03 12424 1.2E-11 1.7E-14 3.1E-05
  1. *Abbreviations: CAF = coded allele frequency; SE = standard error.
  2. P-value for SNP-phenotype association in the sex-combined meta-analysis, not allowing for heterogeneity by sex.
  3. P-value for SNP-phenotype association in the sex-combined meta-analysis, allowing for different effects by sex.
  4. §P-value for heterogeneity by sex.