|  | Prior study | PAGE |  | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Trait | SNP | CA | CAF | Beta (SE), male | Beta (SE), female | PAGE SNP | §R2 | CA | CAF | Required sample size@for 80% power to detect interaction | Beta (SE), male | Beta (SE), female | Phet | Sex with stronger absolute effect (prior, PAGE) |
Significant heterogeneity in PAGE (phet < 0.05) | |||||||||||||||
BUD13 | TG | rs11820589 | A | 0.05 | 0.131 (0.009) | 0.091 (0.008) | rs3135506 | 0.79 | C | 0.06 | 215,337 | 0.16 (0.02) | 0.09 (0.01) | 4.3E-4 | MM |
GCKR | TG | rs1260326 | T | 0.41 | 0.064 (0.005) | 0.050 (0.004) | rs1260326 | - | T | 0.42 | 370,777 | 0.072 (0.009) | 0.046 (0.006) | 0.013 | MM |
LPL | TG | rs13702 | T | 0.70 | 0.070 (0.005) | 0.047 (0.004) | rs328 | 0.39 | C | 0.90 | 389,318 | −0.110 (0.014) | −0.069 (0.009) | 0.013 | MM |
PLTP | HDL | rs6065904 | A | 0.22 | −0.008 (0.003) | −0.031 (0.004) | rs7679 | 0.86 | T | 0.82 | 242,184 | 0.10 (0.30) | 1.68 (0.37) | 9.9E-4 | FF |
TRIB1 | TG | rs2954033 | A | 0.30 | 0.050 (0.005) | 0.022 (0.004) | rs2954029 | 0.36 | A | 0.54 | 137,339 | −0.059 (0.010) | −0.031 (0.006) | 0.015 | MM |
No significant heterogeneity in PAGE (phet > 0.05) | |||||||||||||||
APOB | TG | rs11902417 | A | 0.23 | −0.038 (0.006) | −0.024 (0.005) | rs693 | 0.27 | T | 0.49 | >1,000,000 | −0.025 (0.009) | −0.014 (0.007) | 0.32 | MM |
APOB | LDL | rs531819 | T | 0.15 | −0.092 (0.012) | −0.128 (0.012) | rs562338 | 0.70 | T | 0.19 | 126,763 | −5.32 (0.73) | −5.96 (0.66) | 0.51 | FF |
CETP | HDL | rs7499892 | T | 0.17 | −0.074 (0.004) | −0.091 (0.005) | rs1864163 | 0.57 | A | 0.24 | 525,658 | −2.57 (1.55) | −1.16 (2.68) | 0.65 | FM |
CILP2 ‡ | LDL | rs10401969 | T | 0.07 | 0.15 (0.02) | 0.03 (0.01) | rs16996148 | 1.0 | T | 0.08 | 18,530 | −3.44 (0.96) | −2.11 (0.76) | 0.28 | MM |
FADS1 | HDL | rs174548 | C | 0.70 | 0.015 (0.003) | 0.024 (0.004) | rs174547 | 0.80 | T | 0.66 | 986,476 | 0.82 (0.22) | 0.60 (0.20) | 0.47 | FM |
GALNT2 | HDL | rs2296065 | A | 0.85 | 0.015 (0.004) | 0.030 (0.005) | rs2144300 | 0.26 | T | 0.60 | >1,000,000 | 0.21 (0.19) | 0.63 (0.17) | 0.091 | FF |
GALNT2 | TG | rs2296065 | A | 0.85 | −0.015 (0.007) | −0.027 (0.005) | rs2144300 | 0.26 | T | 0.60 | >1,000,000 | 0.015 (0.008) | 0.019 (0.006) | 0.73 | FF |
LIPC | HDL | rs2070895 | A | 0.22 | 0.033 (0.003) | 0.051 (0.004) | rs261332 | 0.91 | A | 0.20 | 375,405 | 1.77 (0.32) | 1.72 (0.42) | 0.96 | FM |
LIPG | HDL | rs2156552 | A | 0.16 | −0.023 (0.004) | −0.032 (0.005) | rs2156552 | - | T | 0.17 | >1,000,000 | −0.38 (0.24) | −0.56 (0.24) | 0.60 | FF |
LPL | HDL | rs10096633 | A | 0.40 | 0.014 (0.032) | 0.079 (0.011) | rs328 | 0.87 | G | 0.10 | 53,495 | 1.76 (0.31) | 1.93 (0.28) | 0.68 | FF |
LPL ‡ | HDL | rs12678919 | A | 0.12 | −0.20 (0.01) | −0.13 (0.01) | rs328 | 1.0 | G | 0.10 | 40,123 | 1.76 (0.31) | 1.93 (0.28) | 0.68 | MF |
LPL †| HDL | rs2083637 | G | 0.26 | 0.149 | 0.079 | rs328 | 0.43 | G | 0.10 | 93,909 | 1.76 (0.31) | 1.93 (0.28) | 0.68 | MF |
PLTP | TG | rs6073952 | A | 0.19 | 0.009 (0.006) | 0.030 (0.005) | rs7679 | 1.0 | T | 0.82 | 247885 | 0.013 (0.013) | 0.009 (0.011) | 0.82 | FM |
TRIB1 | LDL | rs17321515 | A | 0.52 | 0.022 (0.008) | 0.045 (0.009) | rs2954029 | 0.97 | A | 0.54 | 63691 | 1.98 (0.67) | 2.16 (0.49) | 0.83 | FF |