Table 3 Summary of pathway description from the KEGG Pathway Database
Global Pathway | Subpathway | Pathway | Gene | SNP |
|---|---|---|---|---|
Metabolism | Carbohydrate Metabolism | Galactose metabolism | LCT | rs109697559 |
| Â | Â | Amino sugar and nucleotide sugar metabolism | CHI3L1 | rs41790889 |
| Â | Lipid Metabolism | Glycerophospholipid metabolism | PHOSPHO1 | rs136717249 |
| Â | Metabolism of Terpenoids and Polyketides | Terpenoid backbone biosynthesis | PMVK | rs109349988 |
| Â | Metabolism of Cofactors and Vitamins | Riboflavin metabolism | FLAD1 | rs109349988 |
Genetic Information Processing | Replication and Repair | DNA replication | MCM6 | rs109697559 |
| Â | Folding, Sorting and Degradation | RNA degradation | BTG2 | rs41790889 |
| Â | Translation | Aminoacyl-tRNA biosynthesis | DARS | rs109697559 |
Environmental Information Processing | Signal Transduction | MAPK signaling pathway | CACNB2, PDGFA | rs41683753, rs136287610 |
| Â | Â | ErbB signaling pathway | SHC1 | rs109349988 |
| Â | Signaling Molecules and Interaction | Cell adhesion molecules (CAMs) | CLDN18, ALCAM | rs137294146, rs43341824 |
| Â | Â | Neuroactive ligand-receptor interaction | CHRNB2, GIP, ADORA1 | rs109349988, rs136717249, rs41790889 |
| Â | Â | Cytokine-cytokine receptor interaction | NGFR, PDGFA | rs136717249, rs136287610 |
Cellular Processes | Cell Motility | Regulation of actin cytoskeleton | EZR, PDGFA | rs110607520, rs136287610 |
| Â | Cell Growth and Death | Cell cycle | MCM6 | rs109697559 |
| Â | Â | Apoptosis | PRKAR1B | rs136287610 |
| Â | Cell Communication | Tight junction | CLDN18 | rs137294146 |
| Â | Â | Focal adhesion | SHC1, PDGFA | rs109349988, rs136287610 |
| Â | Â | Gap junction | PDGFA | rs136287610 |
| Â | Transport and Catabolism | Peroxisome | PMVK | rs109349988 |
Organismal Systems | Circulatory System | Cardiac muscle contraction | CACNB2 | rs41683753 |
| Â | Immune System | Leukocyte transendothelial migration | EZR, CLDN18 | rs110607520, rs137294146 |
| Â | Â | Chemokine signaling pathway | GNGT2, SHC1 | rs136717249, rs109349988 |
| Â | Â | Cytosolic DNA-sensing pathway | ADAR | rs109349988 |
| Â | Â | Natural killer cell mediated cytotoxicity | SHC1 | Â |
| Â | Digestive System | Gastric acid secretion | EZR | rs110607520 |
| Â | Â | Carbohydrate digestion and absorption | LCT | rs109697559 |
| Â | Nervous System | Glutamatergic synapse | GNGT2 | rs136717249 |
| Â | Â | GABAergic synapse | GNGT2 | rs136717249 |
| Â | Â | Cholinergic synapse | GNGT2, CHRNB2 | rs136717249, rs109349988 |
| Â | Â | Dopaminergic synapse | GNGT2 | rs136717249 |
| Â | Â | Serotonergic synapse | GNGT2 | rs136717249 |
| Â | Â | Retrograde endocannabinoid signaling | GNGT2, RIMS1 | rs136717249, rs110025080 |
| Â | Â | Synaptic vesicle cycle | RIMS1 | rs110025080 |
| Â | Â | Neurotrophin signaling pathway | SHC1, NGFR | rs109349988, rs136717249 |
| Â | Development | Axon guidance | EFNA3, EFNA4 | rs109349988 |
| Â | Endocrine System | Insulin signaling pathway | SHC1, PRKAR1B | rs109349988, rs136287610 |
Human Diseases | Cardiovascular Diseases | Hypertrophic cardiomyopathy (HCM) | CACNB2 | rs41683753 |
| Â | Â | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNB2 | rs41683753 |
| Â | Â | Dilated cardiomyopathy (DCM) | CACNB2 | rs41683753 |
| Â | Infectious Diseases | Pathogenic Escherichia coli infection | EZR | rs110607520 |
| Â | Â | Hepatitis C | CLDN18 | rs137294146 |
| Â | Â | Measles | ADAR | rs109349988 |
| Â | Â | Influenza A | ADAR | rs109349988 |
| Â | Â | Bacterial invasion of epithelial cells | SHC1 | rs109349988 |
| Â | Â | HTLV-I infection | PDGFA | rs136287610 |
| Â | Substance Dependence | Morphine addiction | GNGT2, ADORA1 | rs136717249, rs41790889 |
| Â | Â | Nicotine addiction | CHRNB2 | rs109349988 |
| Â | Â | Alcoholism | GNGT2, SHC1 | rs136717249, rs109349988 |
| Â | Cancers | Pathways in cancer | CKS1B, PDGFA | rs109349988, rs136287610 |
| Â | Â | Small cell lung cancer | CKS1B | rs109349988 |
| Â | Â | Glioma | SHC1, PDGFA | rs109349988, rs136287610 |
| Â | Â | Chronic myeloid leukemia | SHC1 | rs109349988 |
| Â | Â | Transcriptional misregulation in cancers | NGFR, PDGFA | rs136717249, rs136287610 |
| Â | Â | Melanoma | PDGFA | rs136287610 |
| Â | Â | Prostate cancer | PDGFA | rs136287610 |