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Table 2 Genotype distributions, minor allele frequencies and unadjusted p-values for comparing genotype distribution according to diabetes status, additive allelic effects between diabetes groups

From: Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa

  Non-diabetic Diabetic p-value Overall
N 575 212   787
IRS1     
G/G, n (%) 526 (91.5) 199 (93.9) 0.485 725 (92.1)
G/A, n (%) 48 (8.3) 13 (6.1)   61 (7.7)
A/A, n (%) 1 (0.2) 0 (0)   1 (0.1))
A, n (%) 50 (4.4) 13 (3.1) 0.131 63 (4.0)
HWE (p-value) >0.999 >0.999   >0.999
PPARG     
C/C, n (%) 521 (90.6) 183 (86.3) 0.161 704 (89.4)
C/G, n (%) 53 (9.2) 29 (13.7)   82 (10.4)
G/G, n (%) 1 (0.2) 0 (0)   1 (0.1)
G, n (%) 55 (4.9) 29 (6.8) 0.012 84 (5.3)
HWE (p-value) >0.999 0.605   0.719
  1. HWE, Hardy-Weinberg Equilibrium (HWE p-values are from exact tests). IRS1, Insulin Substrate Receptor 1; PPARG, Peroxisome Proliferator-Activated Receptor Gamma.