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Table 1 Analysis of genotype-environment interactions (GƗE)

From: Genotype-environment interactions for quantitative traits in Korea Associated Resource (KARE) cohorts

Interaction

aTrait

n

bVG/VP

s.e.

cVGE/VP

s.e.

dLRT

P

Genotypeā€‰Ć—ā€‰area interaction

HCT

7169

0.003

0.058

0.165

0.080

4.38

1.8Eā€‰āˆ’ā€‰02

RBC

7169

0.105

0.058

0.155

0.080

3.90

2.4Eā€‰āˆ’ā€‰02

SUP

6570

0.000

0.063

0.269

0.087

11.68

3.2Eā€‰āˆ’ā€‰04

Ā 

WHR

7160

0.014

0.056

0.134

0.076

3.56

3.0Eā€‰āˆ’ā€‰02

Genotypeā€‰Ć—ā€‰sex interaction

DSS

6753

0.054

0.061

0.157

0.085

3.53

3.0Eā€‰āˆ’ā€‰02

SBP

7169

0.179

0.057

0.145

0.080

3.37

3.3Eā€‰āˆ’ā€‰02

SBP0

7170

0.112

0.058

0.218

0.081

7.19

3.7Eā€‰āˆ’ā€‰03

Ā 

SONA

7169

0.000

0.056

0.132

0.080

2.77

4.8Eā€‰āˆ’ā€‰02

Genotypeā€‰Ć—ā€‰age interaction

AST

7169

0.022

0.048

0.148

0.083

3.25

3.6Eā€‰āˆ’ā€‰02

PLAT

7169

0.134

0.050

0.192

0.084

5.36

1.0Eā€‰āˆ’ā€‰02

Ā 

WBC

7169

0.105

0.050

0.159

0.083

3.70

2.7Eā€‰āˆ’ā€‰02

  1. aTrait abbreviations: HCT hematocrit, RBC red blood cells, SUP, supra-iliac skinfold thickness, WHR waist-to-hip ratio, DS distal radius, SBP0 and SBP systolic blood pressure, SONA sodium, AST aspartate transaminase, PLAT platelets, WBC white blood cells. bThe proportion of phenotypic variance explained by the additive genetic effects of all SNPs, h2Gā€‰=ā€‰VG/VP. cThe proportion of phenotypic variance explained by additive-by-environment interaction effects of all SNPs. dThe likelihood ratio test (LRT) for the null hypothesis of VGEā€‰=ā€‰0, where the LRT statistic is distributed as half the probability of 0 and half the probability of Ļ‡12.