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Table 1 Analysis of genotype-environment interactions (G×E)

From: Genotype-environment interactions for quantitative traits in Korea Associated Resource (KARE) cohorts

Interaction aTrait n bVG/VP s.e. cVGE/VP s.e. dLRT P
Genotype × area interaction HCT 7169 0.003 0.058 0.165 0.080 4.38 1.8E − 02
RBC 7169 0.105 0.058 0.155 0.080 3.90 2.4E − 02
SUP 6570 0.000 0.063 0.269 0.087 11.68 3.2E − 04
  WHR 7160 0.014 0.056 0.134 0.076 3.56 3.0E − 02
Genotype × sex interaction DSS 6753 0.054 0.061 0.157 0.085 3.53 3.0E − 02
SBP 7169 0.179 0.057 0.145 0.080 3.37 3.3E − 02
SBP0 7170 0.112 0.058 0.218 0.081 7.19 3.7E − 03
  SONA 7169 0.000 0.056 0.132 0.080 2.77 4.8E − 02
Genotype × age interaction AST 7169 0.022 0.048 0.148 0.083 3.25 3.6E − 02
PLAT 7169 0.134 0.050 0.192 0.084 5.36 1.0E − 02
  WBC 7169 0.105 0.050 0.159 0.083 3.70 2.7E − 02
  1. aTrait abbreviations: HCT hematocrit, RBC red blood cells, SUP, supra-iliac skinfold thickness, WHR waist-to-hip ratio, DS distal radius, SBP0 and SBP systolic blood pressure, SONA sodium, AST aspartate transaminase, PLAT platelets, WBC white blood cells. bThe proportion of phenotypic variance explained by the additive genetic effects of all SNPs, h2G = VG/VP. cThe proportion of phenotypic variance explained by additive-by-environment interaction effects of all SNPs. dThe likelihood ratio test (LRT) for the null hypothesis of VGE = 0, where the LRT statistic is distributed as half the probability of 0 and half the probability of χ12.