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Table 1 The median width in kilo bases (kb) of de novo deletions, stratified by case status and cleft type for both discovery methods

From: A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk

  Controls Clefts p CL p CP p CLP p
MD 71.7 102.7 1e-4 87.8 0.084 95.2 0.067 128.5 1e-5
PennCNV 61.3 70.5 0.051 81.1 0.006 52.5 0.923 85.7 0.041
  1. MD: de novo deletions with coverage of at least ten markers inferred by MinimumDistance[44]; PennCNV: de novo deletions with coverage of at least ten markers inferred by PennCNV[43]. CL: cleft lip; CP: cleft palate; CLP: cleft lip and palate. The p-values were derived using a one-sided Wilcoxon rank-sum test to assess a potential increase in width of de novo deletions in the cleft offspring versus controls.