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Table 1 The median width in kilo bases (kb) of de novo deletions, stratified by case status and cleft type for both discovery methods

From: A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk

 

Controls

Clefts

p

CL

p

CP

p

CLP

p

MD

71.7

102.7

1e-4

87.8

0.084

95.2

0.067

128.5

1e-5

PennCNV

61.3

70.5

0.051

81.1

0.006

52.5

0.923

85.7

0.041

  1. MD: de novo deletions with coverage of at least ten markers inferred by MinimumDistance[44]; PennCNV: de novo deletions with coverage of at least ten markers inferred by PennCNV[43]. CL: cleft lip; CP: cleft palate; CLP: cleft lip and palate. The p-values were derived using a one-sided Wilcoxon rank-sum test to assess a potential increase in width of de novo deletions in the cleft offspring versus controls.